Should you encounter any unexpected behaviour,
please let us know.
elNémo has been relocated.
Some cleaning from time to time
Sorry for the inconvenience.

* HYDROLASE 26-JUL-99 1C2O *

CA strain for 2610021235441786978

--- normal mode 11 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASP 5 PRO 6 -0.0000

PRO 6 GLN 7 0.0003

GLN 7 LEU 8 0.0001

LEU 8 LEU 9 -0.0003

LEU 9 VAL 10 -0.0001

VAL 10 ARG 11 -0.0001

ARG 11 VAL 12 0.0001

VAL 12 ARG 13 -0.0002

ARG 13 GLY 14 -0.0003

GLY 14 GLY 15 -0.0003

GLY 15 GLN 16 -0.0018

GLN 16 LEU 17 -0.0001

LEU 17 ARG 18 -0.0002

ARG 18 GLY 19 0.0004

GLY 19 ILE 20 0.0000

ILE 20 ARG 21 -0.0003

ARG 21 LEU 22 0.0000

LEU 22 LYS 23 0.0002

LYS 23 ALA 24 -0.0002

ALA 24 PRO 25 -0.0000

PRO 25 GLY 26 -0.0001

GLY 26 GLY 27 -0.0042

GLY 27 PRO 28 0.0003

PRO 28 VAL 29 -0.0001

VAL 29 SER 30 0.0001

SER 30 ALA 31 -0.0001

ALA 31 PHE 32 -0.0002

PHE 32 LEU 33 0.0005

LEU 33 GLY 34 -0.0001

GLY 34 ILE 35 0.0004

ILE 35 PRO 36 0.0001

PRO 36 PHE 37 -0.0000

PHE 37 ALA 38 0.0038

ALA 38 GLU 39 -0.0000

GLU 39 PRO 40 -0.0002

PRO 40 PRO 41 -0.0001

PRO 41 VAL 42 -0.0000

VAL 42 GLY 43 0.0002

GLY 43 SER 44 0.0001

SER 44 ARG 45 0.0000

ARG 45 ARG 46 -0.0001

ARG 46 PHE 47 -0.0001

PHE 47 MET 48 -0.0003

MET 48 PRO 49 -0.0014

PRO 49 PRO 50 0.0001

PRO 50 GLU 51 0.0001

GLU 51 PRO 52 -0.0002

PRO 52 LYS 53 -0.0001

LYS 53 ARG 54 -0.0001

ARG 54 PRO 55 -0.0002

PRO 55 TRP 56 -0.0002

TRP 56 SER 57 0.0000

SER 57 GLY 58 -0.0000

GLY 58 VAL 59 0.0000

VAL 59 LEU 60 0.0008

LEU 60 ASP 61 -0.0001

ASP 61 ALA 62 -0.0004

ALA 62 THR 63 0.0001

THR 63 THR 64 0.0002

THR 64 PHE 65 -0.0003

PHE 65 GLN 66 -0.0000

GLN 66 ASN 67 0.0001

ASN 67 VAL 68 0.0001

VAL 68 CYS 69 -0.0004

CYS 69 TYR 70 0.0002

TYR 70 GLN 71 -0.0047

GLN 71 TYR 72 -0.0000

TYR 72 VAL 73 0.0002

VAL 73 ASP 74 -0.0001

ASP 74 THR 75 -0.0002

THR 75 LEU 76 0.0000

LEU 76 TYR 77 0.0001

TYR 77 PRO 78 -0.0002

PRO 78 GLY 79 0.0000

GLY 79 PHE 80 -0.0003

PHE 80 GLU 81 0.0001

GLU 81 GLY 82 0.0177

GLY 82 THR 83 0.0001

THR 83 GLU 84 0.0000

GLU 84 MET 85 -0.0003

MET 85 TRP 86 0.0000

TRP 86 ASN 87 0.0003

ASN 87 PRO 88 0.0001

PRO 88 ASN 89 0.0003

ASN 89 ARG 90 -0.0003

ARG 90 GLU 91 0.0001

GLU 91 LEU 92 -0.0001

LEU 92 SER 93 -0.0149

SER 93 GLU 94 0.0000

GLU 94 ASP 95 -0.0000

ASP 95 CYS 96 0.0001

CYS 96 LEU 97 -0.0003

LEU 97 TYR 98 -0.0003

TYR 98 LEU 99 -0.0001

LEU 99 ASN 100 -0.0000

ASN 100 VAL 101 0.0002

VAL 101 TRP 102 -0.0001

TRP 102 THR 103 -0.0000

THR 103 PRO 104 0.0049

PRO 104 TYR 105 0.0001

TYR 105 PRO 106 -0.0000

PRO 106 ARG 107 -0.0003

ARG 107 PRO 108 0.0002

PRO 108 ALA 109 -0.0001

ALA 109 SER 110 0.0002

SER 110 PRO 111 -0.0001

PRO 111 THR 112 -0.0001

THR 112 PRO 113 -0.0003

PRO 113 VAL 114 -0.0003

VAL 114 LEU 115 0.0021

LEU 115 ILE 116 0.0000

ILE 116 TRP 117 -0.0001

TRP 117 ILE 118 0.0004

ILE 118 TYR 119 0.0002

TYR 119 GLY 120 -0.0003

GLY 120 GLY 121 0.0000

GLY 121 GLY 122 0.0003

GLY 122 PHE 123 0.0002

PHE 123 TYR 124 -0.0001

TYR 124 SER 125 0.0002

SER 125 GLY 126 0.0047

GLY 126 ALA 127 0.0003

ALA 127 ALA 128 -0.0001

ALA 128 SER 129 -0.0000

SER 129 LEU 130 0.0002

LEU 130 ASP 131 -0.0001

ASP 131 VAL 132 -0.0002

VAL 132 TYR 133 0.0001

TYR 133 ASP 134 -0.0000

ASP 134 GLY 135 -0.0002

GLY 135 ARG 136 0.0002

ARG 136 PHE 137 0.0032

PHE 137 LEU 138 -0.0004

LEU 138 ALA 139 0.0001

ALA 139 GLN 140 0.0003

GLN 140 VAL 141 0.0002

VAL 141 GLU 142 -0.0001

GLU 142 GLY 143 0.0003

GLY 143 ALA 144 -0.0002

ALA 144 VAL 145 0.0002

VAL 145 LEU 146 -0.0001

LEU 146 VAL 147 -0.0001

VAL 147 SER 148 0.0051

SER 148 MET 149 -0.0002

MET 149 ASN 150 -0.0001

ASN 150 TYR 151 -0.0001

TYR 151 ARG 152 -0.0006

ARG 152 VAL 153 -0.0000

VAL 153 GLY 154 0.0004

GLY 154 THR 155 -0.0003

THR 155 PHE 156 -0.0004

PHE 156 GLY 157 0.0006

GLY 157 PHE 158 -0.0002

PHE 158 LEU 159 0.0040

LEU 159 ALA 160 0.0003

ALA 160 LEU 161 -0.0003

LEU 161 PRO 162 0.0002

PRO 162 GLY 163 -0.0001

GLY 163 SER 164 -0.0003

SER 164 ARG 165 0.0003

ARG 165 GLU 166 -0.0000

GLU 166 ALA 167 0.0001

ALA 167 PRO 168 0.0001

PRO 168 GLY 169 -0.0003

GLY 169 ASN 170 0.0053

ASN 170 VAL 171 -0.0001

VAL 171 GLY 172 0.0001

GLY 172 LEU 173 -0.0001

LEU 173 LEU 174 0.0000

LEU 174 ASP 175 0.0001

ASP 175 GLN 176 0.0003

GLN 176 ARG 177 -0.0000

ARG 177 LEU 178 -0.0001

LEU 178 ALA 179 -0.0001

ALA 179 LEU 180 -0.0004

LEU 180 GLN 181 0.0046

GLN 181 TRP 182 -0.0003

TRP 182 VAL 183 0.0000

VAL 183 GLN 184 -0.0001

GLN 184 GLU 185 0.0003

GLU 185 ASN 186 0.0002

ASN 186 ILE 187 0.0001

ILE 187 ALA 188 -0.0001

ALA 188 ALA 189 0.0000

ALA 189 PHE 190 -0.0003

PHE 190 GLY 191 0.0001

GLY 191 GLY 192 0.0004

GLY 192 ASP 193 -0.0003

ASP 193 PRO 194 0.0003

PRO 194 MET 195 0.0002

MET 195 SER 196 0.0000

SER 196 VAL 197 -0.0001

VAL 197 THR 198 -0.0000

THR 198 LEU 199 -0.0002

LEU 199 PHE 200 0.0001

PHE 200 GLY 201 0.0000

GLY 201 GLU 202 0.0001

GLU 202 SER 203 0.0088

SER 203 ALA 204 0.0002

ALA 204 GLY 205 -0.0002

GLY 205 ALA 206 0.0002

ALA 206 ALA 207 -0.0004

ALA 207 SER 208 0.0002

SER 208 VAL 209 -0.0002

VAL 209 GLY 210 0.0002

GLY 210 MET 211 -0.0001

MET 211 HIS 212 0.0001

HIS 212 ILE 213 0.0001

ILE 213 LEU 214 -0.0036

LEU 214 SER 215 -0.0001

SER 215 LEU 216 0.0002

LEU 216 PRO 217 0.0000

PRO 217 SER 218 -0.0000

SER 218 ARG 219 -0.0001

ARG 219 SER 220 0.0004

SER 220 LEU 221 -0.0000

LEU 221 PHE 222 -0.0001

PHE 222 HIS 223 0.0000

HIS 223 ARG 224 0.0003

ARG 224 ALA 225 0.0142

ALA 225 VAL 226 -0.0000

VAL 226 LEU 227 -0.0001

LEU 227 GLN 228 0.0002

GLN 228 SER 229 -0.0000

SER 229 GLY 230 -0.0002

GLY 230 THR 231 -0.0001

THR 231 PRO 232 0.0001

PRO 232 ASN 233 0.0001

ASN 233 GLY 234 -0.0002

GLY 234 PRO 235 0.0004

PRO 235 TRP 236 -0.0009

TRP 236 ALA 237 -0.0001

ALA 237 THR 238 0.0004

THR 238 VAL 239 -0.0005

VAL 239 SER 240 0.0002

SER 240 ALA 241 -0.0001

ALA 241 GLY 242 -0.0000

GLY 242 GLU 243 -0.0002

GLU 243 ALA 244 0.0002

ALA 244 ARG 245 0.0004

ARG 245 ARG 246 -0.0004

ARG 246 ARG 247 0.0018

ARG 247 ALA 248 -0.0003

ALA 248 THR 249 -0.0002

THR 249 LEU 250 0.0003

LEU 250 LEU 251 -0.0000

LEU 251 ALA 252 0.0000

ALA 252 ARG 253 0.0001

ARG 253 LEU 254 0.0003

LEU 254 VAL 255 -0.0000

VAL 255 GLY 256 -0.0002

GLY 256 CYS 257 -0.0004

CYS 257 PRO 258 0.0019

PRO 258 PRO 259 -0.0003

PRO 259 GLY 260 0.0002

GLY 260 GLY 261 -0.0001

GLY 261 ALA 262 0.0001

ALA 262 GLY 263 0.0004

GLY 263 GLY 264 -0.0004

GLY 264 ASN 265 -0.0001

ASN 265 ASP 266 0.0001

ASP 266 THR 267 -0.0001

THR 267 GLU 268 -0.0001

GLU 268 LEU 269 0.0011

LEU 269 ILE 270 0.0001

ILE 270 ALA 271 0.0000

ALA 271 CYS 272 -0.0004

CYS 272 LEU 273 -0.0000

LEU 273 ARG 274 0.0002

ARG 274 THR 275 -0.0001

THR 275 ARG 276 0.0001

ARG 276 PRO 277 0.0005

PRO 277 ALA 278 -0.0001

ALA 278 GLN 279 0.0004

GLN 279 ASP 280 0.0049

ASP 280 LEU 281 -0.0003

LEU 281 VAL 282 -0.0001

VAL 282 ASP 283 0.0002

ASP 283 HIS 284 -0.0002

HIS 284 GLU 285 0.0001

GLU 285 TRP 286 -0.0001

TRP 286 HIS 287 -0.0000

HIS 287 VAL 288 -0.0001

VAL 288 LEU 289 -0.0001

LEU 289 PRO 290 0.0003

PRO 290 GLN 291 0.0141

GLN 291 GLU 292 0.0000

GLU 292 SER 293 -0.0001

SER 293 ILE 294 0.0002

ILE 294 PHE 295 -0.0004

PHE 295 ARG 296 0.0004

ARG 296 PHE 297 -0.0001

PHE 297 SER 298 0.0005

SER 298 PHE 299 -0.0000

PHE 299 VAL 300 -0.0001

VAL 300 PRO 301 -0.0000

PRO 301 VAL 302 0.0018

VAL 302 VAL 303 -0.0003

VAL 303 ASP 304 -0.0001

ASP 304 GLY 305 0.0001

GLY 305 ASP 306 0.0003

ASP 306 PHE 307 0.0003

PHE 307 LEU 308 0.0003

LEU 308 SER 309 0.0001

SER 309 ASP 310 0.0004

ASP 310 THR 311 -0.0003

THR 311 PRO 312 0.0002

PRO 312 GLU 313 0.0114

GLU 313 ALA 314 -0.0002

ALA 314 LEU 315 0.0000

LEU 315 ILE 316 0.0004

ILE 316 ASN 317 -0.0001

ASN 317 THR 318 -0.0001

THR 318 GLY 319 0.0001

GLY 319 ASP 320 -0.0004

ASP 320 PHE 321 0.0003

PHE 321 GLN 322 -0.0003

GLN 322 ASP 323 0.0003

ASP 323 LEU 324 -0.0343

LEU 324 GLN 325 -0.0002

GLN 325 VAL 326 0.0004

VAL 326 LEU 327 -0.0004

LEU 327 VAL 328 -0.0001

VAL 328 GLY 329 -0.0000

GLY 329 VAL 330 -0.0000

VAL 330 VAL 331 -0.0000

VAL 331 LYS 332 -0.0001

LYS 332 ASP 333 -0.0001

ASP 333 GLU 334 0.0002

GLU 334 GLY 335 0.0001

GLY 335 SER 336 0.0001

SER 336 TYR 337 -0.0000

TYR 337 PHE 338 0.0002

PHE 338 LEU 339 0.0002

LEU 339 VAL 340 0.0002

VAL 340 TYR 341 -0.0004

TYR 341 GLY 342 -0.0001

GLY 342 VAL 343 -0.0002

VAL 343 PRO 344 -0.0002

PRO 344 GLY 345 0.0004

GLY 345 PHE 346 0.0043

PHE 346 SER 347 0.0001

SER 347 LYS 348 -0.0002

LYS 348 ASP 349 -0.0001

ASP 349 ASN 350 0.0001

ASN 350 GLU 351 0.0003

GLU 351 SER 352 0.0002

SER 352 LEU 353 -0.0002

LEU 353 ILE 354 0.0000

ILE 354 SER 355 0.0002

SER 355 ARG 356 0.0003

ARG 356 ALA 357 -0.0018

ALA 357 GLN 358 -0.0001

GLN 358 PHE 359 0.0002

PHE 359 LEU 360 0.0002

LEU 360 ALA 361 0.0002

ALA 361 GLY 362 0.0004

GLY 362 VAL 363 0.0003

VAL 363 ARG 364 -0.0004

ARG 364 ILE 365 0.0000

ILE 365 GLY 366 0.0000

GLY 366 VAL 367 0.0000

VAL 367 PRO 368 -0.0074

PRO 368 GLN 369 0.0000

GLN 369 ALA 370 -0.0005

ALA 370 SER 371 0.0001

SER 371 ASP 372 0.0002

ASP 372 LEU 373 -0.0002

LEU 373 ALA 374 -0.0002

ALA 374 ALA 375 -0.0000

ALA 375 GLU 376 0.0001

GLU 376 ALA 377 -0.0002

ALA 377 VAL 378 0.0000

VAL 378 VAL 379 0.0099

VAL 379 LEU 380 0.0004

LEU 380 HIS 381 0.0001

HIS 381 TYR 382 0.0000

TYR 382 THR 383 -0.0002

THR 383 ASP 384 0.0000

ASP 384 TRP 385 -0.0001

TRP 385 LEU 386 -0.0001

LEU 386 HIS 387 -0.0001

HIS 387 PRO 388 -0.0001

PRO 388 GLU 389 -0.0000

GLU 389 ASP 390 -0.0310

ASP 390 PRO 391 0.0001

PRO 391 THR 392 0.0001

THR 392 HIS 393 0.0002

HIS 393 LEU 394 0.0000

LEU 394 ARG 395 0.0001

ARG 395 ASP 396 0.0002

ASP 396 ALA 397 -0.0001

ALA 397 MET 398 -0.0003

MET 398 SER 399 0.0002

SER 399 ALA 400 -0.0004

ALA 400 VAL 401 0.0088

VAL 401 VAL 402 0.0000

VAL 402 GLY 403 -0.0002

GLY 403 ASP 404 0.0002

ASP 404 HIS 405 -0.0000

HIS 405 ASN 406 -0.0001

ASN 406 VAL 407 0.0004

VAL 407 VAL 408 -0.0003

VAL 408 CYS 409 -0.0001

CYS 409 PRO 410 -0.0001

PRO 410 VAL 411 0.0001

VAL 411 ALA 412 0.0058

ALA 412 GLN 413 -0.0001

GLN 413 LEU 414 -0.0002

LEU 414 ALA 415 0.0001

ALA 415 GLY 416 -0.0003

GLY 416 ARG 417 -0.0001

ARG 417 LEU 418 0.0001

LEU 418 ALA 419 0.0001

ALA 419 ALA 420 0.0001

ALA 420 GLN 421 0.0003

GLN 421 GLY 422 -0.0001

GLY 422 ALA 423 -0.0203

ALA 423 ARG 424 -0.0001

ARG 424 VAL 425 0.0002

VAL 425 TYR 426 0.0001

TYR 426 ALA 427 -0.0001

ALA 427 TYR 428 0.0002

TYR 428 ILE 429 -0.0004

ILE 429 PHE 430 -0.0000

PHE 430 GLU 431 0.0001

GLU 431 HIS 432 -0.0000

HIS 432 ARG 433 0.0002

ARG 433 ALA 434 0.0052

ALA 434 SER 435 -0.0001

SER 435 THR 436 0.0000

THR 436 LEU 437 0.0001

LEU 437 THR 438 0.0000

THR 438 TRP 439 0.0003

TRP 439 PRO 440 -0.0004

PRO 440 LEU 441 0.0003

LEU 441 TRP 442 0.0003

TRP 442 MET 443 0.0001

MET 443 GLY 444 -0.0001

GLY 444 VAL 445 0.0085

VAL 445 PRO 446 0.0002

PRO 446 HIS 447 0.0000

HIS 447 GLY 448 0.0001

GLY 448 TYR 449 0.0003

TYR 449 GLU 450 0.0003

GLU 450 ILE 451 0.0000

ILE 451 GLU 452 0.0001

GLU 452 PHE 453 0.0000

PHE 453 ILE 454 0.0003

ILE 454 PHE 455 -0.0000

PHE 455 GLY 456 0.0014

GLY 456 LEU 457 0.0003

LEU 457 PRO 458 -0.0001

PRO 458 LEU 459 -0.0001

LEU 459 ASP 460 0.0001

ASP 460 PRO 461 0.0001

PRO 461 SER 462 0.0001

SER 462 LEU 463 0.0001

LEU 463 ASN 464 -0.0004

ASN 464 TYR 465 0.0002

TYR 465 THR 466 -0.0002

THR 466 THR 467 -0.0009

THR 467 GLU 468 0.0000

GLU 468 GLU 469 -0.0000

GLU 469 ARG 470 -0.0001

ARG 470 ILE 471 0.0002

ILE 471 PHE 472 -0.0002

PHE 472 ALA 473 -0.0002

ALA 473 GLN 474 0.0003

GLN 474 ARG 475 0.0002

ARG 475 LEU 476 -0.0000

LEU 476 MET 477 0.0001

MET 477 LYS 478 0.0015

LYS 478 TYR 479 -0.0005

TYR 479 TRP 480 -0.0004

TRP 480 THR 481 -0.0000

THR 481 ASN 482 -0.0001

ASN 482 PHE 483 -0.0001

PHE 483 ALA 484 -0.0000

ALA 484 ARG 485 0.0003

ARG 485 THR 486 0.0001

THR 486 GLY 487 0.0001

GLY 487 ASP 488 0.0002

ASP 488 PRO 489 -0.0008

PRO 489 ASN 490 -0.0001

ASN 490 ASP 491 -0.0000

ASP 491 PRO 492 0.0003

PRO 492 ARG 493 -0.0001

ARG 493 ASP 494 0.0001

ASP 494 SER 495 0.0002

SER 495 LYS 496 0.0004

LYS 496 SER 497 0.0001

SER 497 PRO 498 -0.0000

PRO 498 GLN 499 0.0001

GLN 499 TRP 500 -0.0012

TRP 500 PRO 501 0.0002

PRO 501 PRO 502 -0.0002

PRO 502 TYR 503 -0.0005

TYR 503 THR 504 0.0002

THR 504 THR 505 0.0001

THR 505 ALA 506 0.0001

ALA 506 ALA 507 -0.0000

ALA 507 GLN 508 -0.0001

GLN 508 GLN 509 -0.0002

GLN 509 TYR 510 -0.0004

TYR 510 VAL 511 -0.0006

VAL 511 SER 512 -0.0001

SER 512 LEU 513 0.0004

LEU 513 ASN 514 -0.0001

ASN 514 LEU 515 -0.0000

LEU 515 LYS 516 -0.0004

LYS 516 PRO 517 -0.0000

PRO 517 LEU 518 0.0001

LEU 518 GLU 519 -0.0003

GLU 519 VAL 520 0.0000

VAL 520 ARG 521 0.0004

ARG 521 ARG 522 -0.0252

ARG 522 GLY 523 0.0001

GLY 523 LEU 524 -0.0003

LEU 524 ARG 525 0.0004

ARG 525 ALA 526 -0.0001

ALA 526 GLN 527 -0.0001

GLN 527 THR 528 -0.0000

THR 528 CYS 529 -0.0001

CYS 529 ALA 530 -0.0002

ALA 530 PHE 531 0.0000

PHE 531 TRP 532 -0.0001

TRP 532 ASN 533 0.0213

ASN 533 ARG 534 -0.0002

ARG 534 PHE 535 -0.0004

PHE 535 LEU 536 -0.0000

LEU 536 PRO 537 0.0002

PRO 537 LYS 538 -0.0000

LYS 538 LEU 539 0.0001

LEU 539 LEU 540 0.0005

LEU 540 SER 541 -0.0000

SER 541 ALA 542 0.0006

ALA 542 THR 543 0.0001

THR 543 ASP 5 0.0222

ASP 5 PRO 6 -0.0003

PRO 6 GLN 7 0.0001

GLN 7 LEU 8 -0.0001

LEU 8 LEU 9 -0.0004

LEU 9 VAL 10 -0.0001

VAL 10 ARG 11 0.0002

ARG 11 VAL 12 0.0000

VAL 12 ARG 13 -0.0000

ARG 13 GLY 14 -0.0000

GLY 14 GLY 15 -0.0000

GLY 15 GLN 16 -0.0020

GLN 16 LEU 17 0.0001

LEU 17 ARG 18 -0.0002

ARG 18 GLY 19 -0.0001

GLY 19 ILE 20 -0.0003

ILE 20 ARG 21 -0.0001

ARG 21 LEU 22 -0.0000

LEU 22 LYS 23 -0.0001

LYS 23 ALA 24 -0.0001

ALA 24 PRO 25 0.0002

PRO 25 GLY 26 0.0001

GLY 26 GLY 27 -0.0011

GLY 27 PRO 28 -0.0000

PRO 28 VAL 29 0.0003

VAL 29 SER 30 0.0002

SER 30 ALA 31 0.0001

ALA 31 PHE 32 -0.0001

PHE 32 LEU 33 -0.0002

LEU 33 GLY 34 0.0001

GLY 34 ILE 35 0.0001

ILE 35 PRO 36 -0.0001

PRO 36 PHE 37 0.0001

PHE 37 ALA 38 0.0261

ALA 38 GLU 39 0.0001

GLU 39 PRO 40 0.0004

PRO 40 PRO 41 0.0001

PRO 41 VAL 42 -0.0002

VAL 42 GLY 43 0.0001

GLY 43 SER 44 0.0003

SER 44 ARG 45 -0.0004

ARG 45 ARG 46 0.0000

ARG 46 PHE 47 0.0002

PHE 47 MET 48 -0.0000

MET 48 PRO 49 0.0073

PRO 49 PRO 50 0.0001

PRO 50 GLU 51 0.0003

GLU 51 PRO 52 -0.0002

PRO 52 LYS 53 0.0001

LYS 53 ARG 54 0.0001

ARG 54 PRO 55 0.0003

PRO 55 TRP 56 -0.0001

TRP 56 SER 57 -0.0001

SER 57 GLY 58 -0.0000

GLY 58 VAL 59 -0.0001

VAL 59 LEU 60 -0.0015

LEU 60 ASP 61 0.0003

ASP 61 ALA 62 0.0001

ALA 62 THR 63 -0.0001

THR 63 THR 64 -0.0000

THR 64 PHE 65 -0.0001

PHE 65 GLN 66 -0.0005

GLN 66 ASN 67 0.0002

ASN 67 VAL 68 0.0001

VAL 68 CYS 69 0.0002

CYS 69 TYR 70 -0.0004

TYR 70 GLN 71 -0.0059

GLN 71 TYR 72 -0.0001

TYR 72 VAL 73 -0.0000

VAL 73 ASP 74 0.0001

ASP 74 THR 75 -0.0003

THR 75 LEU 76 0.0003

LEU 76 TYR 77 0.0003

TYR 77 PRO 78 -0.0000

PRO 78 GLY 79 -0.0001

GLY 79 PHE 80 -0.0005

PHE 80 GLU 81 -0.0002

GLU 81 GLY 82 0.0100

GLY 82 THR 83 -0.0002

THR 83 GLU 84 0.0000

GLU 84 MET 85 0.0001

MET 85 TRP 86 0.0002

TRP 86 ASN 87 -0.0002

ASN 87 PRO 88 0.0004

PRO 88 ASN 89 -0.0004

ASN 89 ARG 90 -0.0004

ARG 90 GLU 91 0.0001

GLU 91 LEU 92 0.0001

LEU 92 SER 93 -0.0172

SER 93 GLU 94 0.0005

GLU 94 ASP 95 -0.0002

ASP 95 CYS 96 -0.0001

CYS 96 LEU 97 -0.0001

LEU 97 TYR 98 0.0001

TYR 98 LEU 99 -0.0003

LEU 99 ASN 100 -0.0001

ASN 100 VAL 101 0.0001

VAL 101 TRP 102 -0.0003

TRP 102 THR 103 -0.0002

THR 103 PRO 104 0.0074

PRO 104 TYR 105 -0.0003

TYR 105 PRO 106 -0.0002

PRO 106 ARG 107 0.0003

ARG 107 PRO 108 0.0002

PRO 108 ALA 109 -0.0000

ALA 109 SER 110 -0.0001

SER 110 PRO 111 0.0002

PRO 111 THR 112 -0.0002

THR 112 PRO 113 -0.0003

PRO 113 VAL 114 -0.0002

VAL 114 LEU 115 -0.0061

LEU 115 ILE 116 0.0002

ILE 116 TRP 117 -0.0000

TRP 117 ILE 118 -0.0001

ILE 118 TYR 119 -0.0000

TYR 119 GLY 120 0.0003

GLY 120 GLY 121 -0.0001

GLY 121 GLY 122 0.0002

GLY 122 PHE 123 0.0001

PHE 123 TYR 124 0.0002

TYR 124 SER 125 -0.0001

SER 125 GLY 126 -0.0013

GLY 126 ALA 127 0.0004

ALA 127 ALA 128 -0.0002

ALA 128 SER 129 0.0000

SER 129 LEU 130 0.0002

LEU 130 ASP 131 -0.0003

ASP 131 VAL 132 0.0003

VAL 132 TYR 133 -0.0002

TYR 133 ASP 134 -0.0004

ASP 134 GLY 135 0.0004

GLY 135 ARG 136 -0.0001

ARG 136 PHE 137 0.0026

PHE 137 LEU 138 -0.0001

LEU 138 ALA 139 0.0003

ALA 139 GLN 140 -0.0001

GLN 140 VAL 141 -0.0003

VAL 141 GLU 142 0.0000

GLU 142 GLY 143 0.0000

GLY 143 ALA 144 -0.0002

ALA 144 VAL 145 0.0001

VAL 145 LEU 146 -0.0002

LEU 146 VAL 147 0.0002

VAL 147 SER 148 0.0007

SER 148 MET 149 0.0003

MET 149 ASN 150 0.0000

ASN 150 TYR 151 0.0002

TYR 151 ARG 152 -0.0000

ARG 152 VAL 153 -0.0001

VAL 153 GLY 154 0.0003

GLY 154 THR 155 -0.0003

THR 155 PHE 156 0.0001

PHE 156 GLY 157 0.0005

GLY 157 PHE 158 -0.0001

PHE 158 LEU 159 -0.0062

LEU 159 ALA 160 0.0003

ALA 160 LEU 161 -0.0003

LEU 161 PRO 162 0.0002

PRO 162 GLY 163 0.0001

GLY 163 SER 164 0.0000

SER 164 ARG 165 0.0001

ARG 165 GLU 166 -0.0000

GLU 166 ALA 167 -0.0001

ALA 167 PRO 168 0.0000

PRO 168 GLY 169 0.0003

GLY 169 ASN 170 0.0067

ASN 170 VAL 171 -0.0002

VAL 171 GLY 172 -0.0001

GLY 172 LEU 173 0.0002

LEU 173 LEU 174 -0.0002

LEU 174 ASP 175 0.0000

ASP 175 GLN 176 0.0002

GLN 176 ARG 177 -0.0002

ARG 177 LEU 178 0.0003

LEU 178 ALA 179 -0.0000

ALA 179 LEU 180 0.0005

LEU 180 GLN 181 -0.0032

GLN 181 TRP 182 0.0001

TRP 182 VAL 183 -0.0001

VAL 183 GLN 184 0.0000

GLN 184 GLU 185 0.0002

GLU 185 ASN 186 0.0004

ASN 186 ILE 187 -0.0003

ILE 187 ALA 188 -0.0003

ALA 188 ALA 189 -0.0000

ALA 189 PHE 190 0.0001

PHE 190 GLY 191 0.0000

GLY 191 GLY 192 0.0003

GLY 192 ASP 193 -0.0001

ASP 193 PRO 194 0.0004

PRO 194 MET 195 0.0001

MET 195 SER 196 0.0003

SER 196 VAL 197 -0.0000

VAL 197 THR 198 0.0004

THR 198 LEU 199 -0.0000

LEU 199 PHE 200 -0.0003

PHE 200 GLY 201 0.0002

GLY 201 GLU 202 -0.0001

GLU 202 SER 203 -0.0031

SER 203 ALA 204 -0.0002

ALA 204 GLY 205 0.0002

GLY 205 ALA 206 0.0002

ALA 206 ALA 207 0.0002

ALA 207 SER 208 0.0000

SER 208 VAL 209 0.0004

VAL 209 GLY 210 0.0001

GLY 210 MET 211 -0.0001

MET 211 HIS 212 0.0001

HIS 212 ILE 213 -0.0002

ILE 213 LEU 214 0.0019

LEU 214 SER 215 -0.0000

SER 215 LEU 216 0.0001

LEU 216 PRO 217 -0.0002

PRO 217 SER 218 -0.0002

SER 218 ARG 219 -0.0001

ARG 219 SER 220 0.0001

SER 220 LEU 221 -0.0003

LEU 221 PHE 222 -0.0004

PHE 222 HIS 223 -0.0002

HIS 223 ARG 224 -0.0003

ARG 224 ALA 225 0.0026

ALA 225 VAL 226 -0.0004

VAL 226 LEU 227 0.0003

LEU 227 GLN 228 -0.0002

GLN 228 SER 229 0.0003

SER 229 GLY 230 0.0001

GLY 230 THR 231 0.0000

THR 231 PRO 232 -0.0001

PRO 232 ASN 233 -0.0002

ASN 233 GLY 234 0.0001

GLY 234 PRO 235 0.0000

PRO 235 TRP 236 -0.0247

TRP 236 ALA 237 0.0001

ALA 237 THR 238 -0.0003

THR 238 VAL 239 0.0002

VAL 239 SER 240 -0.0000

SER 240 ALA 241 0.0004

ALA 241 GLY 242 -0.0002

GLY 242 GLU 243 -0.0000

GLU 243 ALA 244 0.0002

ALA 244 ARG 245 -0.0002

ARG 245 ARG 246 -0.0001

ARG 246 ARG 247 0.0224

ARG 247 ALA 248 -0.0002

ALA 248 THR 249 0.0004

THR 249 LEU 250 0.0002

LEU 250 LEU 251 -0.0001

LEU 251 ALA 252 0.0004

ALA 252 ARG 253 0.0001

ARG 253 LEU 254 0.0003

LEU 254 VAL 255 0.0000

VAL 255 GLY 256 0.0006

GLY 256 CYS 257 -0.0001

CYS 257 PRO 258 -0.0362

PRO 258 PRO 259 -0.0002

PRO 259 GLY 260 0.0002

GLY 260 GLY 261 -0.0002

GLY 261 ALA 262 -0.0000

ALA 262 GLY 263 0.0002

GLY 263 GLY 264 -0.0001

GLY 264 ASN 265 -0.0003

ASN 265 ASP 266 0.0001

ASP 266 THR 267 0.0003

THR 267 GLU 268 0.0001

GLU 268 LEU 269 -0.0176

LEU 269 ILE 270 0.0000

ILE 270 ALA 271 -0.0004

ALA 271 CYS 272 0.0002

CYS 272 LEU 273 0.0000

LEU 273 ARG 274 -0.0004

ARG 274 THR 275 -0.0000

THR 275 ARG 276 -0.0002

ARG 276 PRO 277 -0.0002

PRO 277 ALA 278 0.0000

ALA 278 GLN 279 -0.0000

GLN 279 ASP 280 0.0148

ASP 280 LEU 281 0.0002

LEU 281 VAL 282 0.0004

VAL 282 ASP 283 0.0004

ASP 283 HIS 284 -0.0003

HIS 284 GLU 285 -0.0002

GLU 285 TRP 286 -0.0003

TRP 286 HIS 287 -0.0001

HIS 287 VAL 288 -0.0001

VAL 288 LEU 289 0.0000

LEU 289 PRO 290 -0.0003

PRO 290 GLN 291 -0.0187

GLN 291 GLU 292 0.0001

GLU 292 SER 293 0.0002

SER 293 ILE 294 -0.0002

ILE 294 PHE 295 -0.0001

PHE 295 ARG 296 0.0003

ARG 296 PHE 297 -0.0000

PHE 297 SER 298 -0.0003

SER 298 PHE 299 0.0003

PHE 299 VAL 300 -0.0003

VAL 300 PRO 301 0.0003

PRO 301 VAL 302 -0.0053

VAL 302 VAL 303 -0.0002

VAL 303 ASP 304 0.0002

ASP 304 GLY 305 0.0001

GLY 305 ASP 306 -0.0003

ASP 306 PHE 307 0.0002

PHE 307 LEU 308 0.0003

LEU 308 SER 309 0.0000

SER 309 ASP 310 -0.0001

ASP 310 THR 311 0.0000

THR 311 PRO 312 -0.0000

PRO 312 GLU 313 -0.0033

GLU 313 ALA 314 0.0002

ALA 314 LEU 315 -0.0000

LEU 315 ILE 316 -0.0002

ILE 316 ASN 317 0.0000

ASN 317 THR 318 -0.0004

THR 318 GLY 319 0.0000

GLY 319 ASP 320 0.0002

ASP 320 PHE 321 -0.0002

PHE 321 GLN 322 0.0003

GLN 322 ASP 323 -0.0001

ASP 323 LEU 324 0.0035

LEU 324 GLN 325 -0.0000

GLN 325 VAL 326 0.0003

VAL 326 LEU 327 -0.0005

LEU 327 VAL 328 -0.0002

VAL 328 GLY 329 0.0001

GLY 329 VAL 330 0.0004

VAL 330 VAL 331 -0.0000

VAL 331 LYS 332 0.0001

LYS 332 ASP 333 -0.0005

ASP 333 GLU 334 -0.0002

GLU 334 GLY 335 0.0055

GLY 335 SER 336 -0.0000

SER 336 TYR 337 -0.0003

TYR 337 PHE 338 0.0000

PHE 338 LEU 339 -0.0000

LEU 339 VAL 340 0.0000

VAL 340 TYR 341 -0.0001

TYR 341 GLY 342 0.0002

GLY 342 VAL 343 -0.0002

VAL 343 PRO 344 0.0003

PRO 344 GLY 345 -0.0004

GLY 345 PHE 346 0.0009

PHE 346 SER 347 0.0002

SER 347 LYS 348 -0.0002

LYS 348 ASP 349 -0.0002

ASP 349 ASN 350 -0.0001

ASN 350 GLU 351 -0.0001

GLU 351 SER 352 0.0001

SER 352 LEU 353 -0.0000

LEU 353 ILE 354 -0.0003

ILE 354 SER 355 0.0003

SER 355 ARG 356 -0.0002

ARG 356 ALA 357 -0.0027

ALA 357 GLN 358 0.0000

GLN 358 PHE 359 0.0003

PHE 359 LEU 360 -0.0001

LEU 360 ALA 361 0.0001

ALA 361 GLY 362 0.0001

GLY 362 VAL 363 -0.0001

VAL 363 ARG 364 -0.0000

ARG 364 ILE 365 0.0004

ILE 365 GLY 366 -0.0005

GLY 366 VAL 367 -0.0001

VAL 367 PRO 368 -0.0007

PRO 368 GLN 369 -0.0002

GLN 369 ALA 370 -0.0004

ALA 370 SER 371 0.0000

SER 371 ASP 372 -0.0003

ASP 372 LEU 373 0.0002

LEU 373 ALA 374 0.0001

ALA 374 ALA 375 -0.0005

ALA 375 GLU 376 0.0003

GLU 376 ALA 377 0.0001

ALA 377 VAL 378 -0.0003

VAL 378 VAL 379 -0.0064

VAL 379 LEU 380 0.0000

LEU 380 HIS 381 0.0001

HIS 381 TYR 382 0.0002

TYR 382 THR 383 0.0000

THR 383 ASP 384 -0.0002

ASP 384 TRP 385 0.0002

TRP 385 LEU 386 0.0001

LEU 386 HIS 387 -0.0000

HIS 387 PRO 388 -0.0004

PRO 388 GLU 389 0.0003

GLU 389 ASP 390 0.0087

ASP 390 PRO 391 -0.0001

PRO 391 THR 392 0.0005

THR 392 HIS 393 0.0003

HIS 393 LEU 394 0.0001

LEU 394 ARG 395 0.0000

ARG 395 ASP 396 -0.0000

ASP 396 ALA 397 -0.0001

ALA 397 MET 398 -0.0001

MET 398 SER 399 0.0001

SER 399 ALA 400 0.0004

ALA 400 VAL 401 -0.0067

VAL 401 VAL 402 0.0003

VAL 402 GLY 403 -0.0000

GLY 403 ASP 404 -0.0001

ASP 404 HIS 405 -0.0002

HIS 405 ASN 406 0.0004

ASN 406 VAL 407 -0.0002

VAL 407 VAL 408 0.0000

VAL 408 CYS 409 -0.0002

CYS 409 PRO 410 -0.0002

PRO 410 VAL 411 0.0000

VAL 411 ALA 412 -0.0074

ALA 412 GLN 413 -0.0002

GLN 413 LEU 414 -0.0001

LEU 414 ALA 415 0.0001

ALA 415 GLY 416 0.0002

GLY 416 ARG 417 0.0003

ARG 417 LEU 418 -0.0003

LEU 418 ALA 419 0.0001

ALA 419 ALA 420 -0.0003

ALA 420 GLN 421 0.0000

GLN 421 GLY 422 0.0002

GLY 422 ALA 423 -0.0065

ALA 423 ARG 424 0.0000

ARG 424 VAL 425 0.0003

VAL 425 TYR 426 -0.0002

TYR 426 ALA 427 0.0001

ALA 427 TYR 428 -0.0003

TYR 428 ILE 429 -0.0001

ILE 429 PHE 430 -0.0001

PHE 430 GLU 431 0.0001

GLU 431 HIS 432 -0.0005

HIS 432 ARG 433 0.0003

ARG 433 ALA 434 -0.0049

ALA 434 SER 435 0.0002

SER 435 THR 436 -0.0002

THR 436 LEU 437 0.0005

LEU 437 THR 438 -0.0002

THR 438 TRP 439 0.0003

TRP 439 PRO 440 -0.0001

PRO 440 LEU 441 0.0003

LEU 441 TRP 442 0.0004

TRP 442 MET 443 -0.0002

MET 443 GLY 444 -0.0001

GLY 444 VAL 445 0.0064

VAL 445 PRO 446 0.0001

PRO 446 HIS 447 -0.0002

HIS 447 GLY 448 -0.0001

GLY 448 TYR 449 0.0001

TYR 449 GLU 450 -0.0001

GLU 450 ILE 451 0.0003

ILE 451 GLU 452 0.0001

GLU 452 PHE 453 0.0002

PHE 453 ILE 454 0.0003

ILE 454 PHE 455 0.0003

PHE 455 GLY 456 -0.0016

GLY 456 LEU 457 -0.0002

LEU 457 PRO 458 -0.0002

PRO 458 LEU 459 0.0004

LEU 459 ASP 460 0.0003

ASP 460 PRO 461 0.0003

PRO 461 SER 462 -0.0005

SER 462 LEU 463 -0.0001

LEU 463 ASN 464 0.0001

ASN 464 TYR 465 -0.0001

TYR 465 THR 466 -0.0003

THR 466 THR 467 -0.0026

THR 467 GLU 468 -0.0001

GLU 468 GLU 469 0.0001

GLU 469 ARG 470 -0.0001

ARG 470 ILE 471 0.0001

ILE 471 PHE 472 -0.0004

PHE 472 ALA 473 0.0001

ALA 473 GLN 474 -0.0004

GLN 474 ARG 475 -0.0001

ARG 475 LEU 476 0.0001

LEU 476 MET 477 -0.0000

MET 477 LYS 478 -0.0007

LYS 478 TYR 479 0.0002

TYR 479 TRP 480 0.0000

TRP 480 THR 481 0.0003

THR 481 ASN 482 -0.0001

ASN 482 PHE 483 -0.0001

PHE 483 ALA 484 0.0000

ALA 484 ARG 485 -0.0003

ARG 485 THR 486 0.0003

THR 486 GLY 487 0.0002

GLY 487 ASP 488 -0.0003

ASP 488 PRO 489 0.0016

PRO 489 ASN 490 -0.0003

ASN 490 ASP 491 -0.0001

ASP 491 PRO 492 0.0001

PRO 492 ARG 493 -0.0003

ARG 493 ASP 494 -0.0001

ASP 494 SER 495 0.0001

SER 495 LYS 496 -0.0002

LYS 496 SER 497 -0.0001

SER 497 PRO 498 0.0002

PRO 498 GLN 499 0.0000

GLN 499 TRP 500 -0.0018

TRP 500 PRO 501 0.0000

PRO 501 PRO 502 -0.0000

PRO 502 TYR 503 -0.0000

TYR 503 THR 504 0.0002

THR 504 THR 505 -0.0002

THR 505 ALA 506 0.0002

ALA 506 ALA 507 0.0002

ALA 507 GLN 508 -0.0002

GLN 508 GLN 509 -0.0001

GLN 509 TYR 510 0.0004

TYR 510 VAL 511 0.0022

VAL 511 SER 512 0.0002

SER 512 LEU 513 0.0001

LEU 513 ASN 514 0.0001

ASN 514 LEU 515 0.0003

LEU 515 LYS 516 0.0001

LYS 516 PRO 517 -0.0003

PRO 517 LEU 518 -0.0002

LEU 518 GLU 519 0.0003

GLU 519 VAL 520 -0.0004

VAL 520 ARG 521 0.0001

ARG 521 ARG 522 0.0331

ARG 522 GLY 523 0.0002

GLY 523 LEU 524 0.0002

LEU 524 ARG 525 0.0001

ARG 525 ALA 526 -0.0002

ALA 526 GLN 527 0.0000

GLN 527 THR 528 -0.0000

THR 528 CYS 529 -0.0000

CYS 529 ALA 530 0.0000

ALA 530 PHE 531 -0.0005

PHE 531 TRP 532 -0.0001

TRP 532 ASN 533 0.0028

ASN 533 ARG 534 -0.0001

ARG 534 PHE 535 -0.0001

PHE 535 LEU 536 0.0003

LEU 536 PRO 537 0.0003

PRO 537 LYS 538 -0.0001

LYS 538 LEU 539 0.0003

LEU 539 LEU 540 -0.0000

LEU 540 SER 541 0.0001

SER 541 ALA 542 -0.0001

ALA 542 THR 543 0.0000

THR 543 ASP 5 0.0077

ASP 5 PRO 6 0.0004

PRO 6 GLN 7 0.0000

GLN 7 LEU 8 -0.0003

LEU 8 LEU 9 0.0000

LEU 9 VAL 10 0.0002

VAL 10 ARG 11 0.0000

ARG 11 VAL 12 0.0005

VAL 12 ARG 13 -0.0004

ARG 13 GLY 14 0.0002

GLY 14 GLY 15 -0.0002

GLY 15 GLN 16 -0.0022

GLN 16 LEU 17 0.0003

LEU 17 ARG 18 -0.0003

ARG 18 GLY 19 0.0005

GLY 19 ILE 20 0.0001

ILE 20 ARG 21 0.0000

ARG 21 LEU 22 0.0002

LEU 22 LYS 23 -0.0000

LYS 23 ALA 24 -0.0001

ALA 24 PRO 25 -0.0001

PRO 25 GLY 26 -0.0002

GLY 26 GLY 27 -0.0036

GLY 27 PRO 28 0.0001

PRO 28 VAL 29 -0.0003

VAL 29 SER 30 -0.0002

SER 30 ALA 31 -0.0000

ALA 31 PHE 32 0.0003

PHE 32 LEU 33 -0.0002

LEU 33 GLY 34 0.0002

GLY 34 ILE 35 0.0001

ILE 35 PRO 36 -0.0000

PRO 36 PHE 37 0.0001

PHE 37 ALA 38 0.0034

ALA 38 GLU 39 -0.0001

GLU 39 PRO 40 0.0000

PRO 40 PRO 41 0.0001

PRO 41 VAL 42 0.0003

VAL 42 GLY 43 0.0001

GLY 43 SER 44 0.0004

SER 44 ARG 45 0.0000

ARG 45 ARG 46 0.0001

ARG 46 PHE 47 -0.0001

PHE 47 MET 48 -0.0003

MET 48 PRO 49 -0.0021

PRO 49 PRO 50 -0.0000

PRO 50 GLU 51 0.0002

GLU 51 PRO 52 0.0001

PRO 52 LYS 53 -0.0002

LYS 53 ARG 54 0.0000

ARG 54 PRO 55 0.0000

PRO 55 TRP 56 -0.0002

TRP 56 SER 57 0.0003

SER 57 GLY 58 -0.0000

GLY 58 VAL 59 0.0000

VAL 59 LEU 60 0.0007

LEU 60 ASP 61 -0.0001

ASP 61 ALA 62 0.0001

ALA 62 THR 63 0.0001

THR 63 THR 64 0.0002

THR 64 PHE 65 -0.0002

PHE 65 GLN 66 -0.0001

GLN 66 ASN 67 -0.0003

ASN 67 VAL 68 0.0003

VAL 68 CYS 69 0.0004

CYS 69 TYR 70 -0.0000

TYR 70 GLN 71 -0.0055

GLN 71 TYR 72 0.0002

TYR 72 VAL 73 -0.0001

VAL 73 ASP 74 -0.0001

ASP 74 THR 75 0.0001

THR 75 LEU 76 0.0001

LEU 76 TYR 77 0.0001

TYR 77 PRO 78 0.0005

PRO 78 GLY 79 -0.0001

GLY 79 PHE 80 0.0004

PHE 80 GLU 81 0.0000

GLU 81 GLY 82 0.0167

GLY 82 THR 83 -0.0000

THR 83 GLU 84 -0.0001

GLU 84 MET 85 0.0003

MET 85 TRP 86 0.0002

TRP 86 ASN 87 0.0002

ASN 87 PRO 88 -0.0001

PRO 88 ASN 89 0.0003

ASN 89 ARG 90 -0.0001

ARG 90 GLU 91 0.0002

GLU 91 LEU 92 -0.0001

LEU 92 SER 93 -0.0152

SER 93 GLU 94 -0.0003

GLU 94 ASP 95 0.0001

ASP 95 CYS 96 0.0002

CYS 96 LEU 97 0.0001

LEU 97 TYR 98 -0.0002

TYR 98 LEU 99 0.0003

LEU 99 ASN 100 -0.0001

ASN 100 VAL 101 -0.0001

VAL 101 TRP 102 -0.0003

TRP 102 THR 103 0.0001

THR 103 PRO 104 0.0045

PRO 104 TYR 105 0.0003

TYR 105 PRO 106 -0.0001

PRO 106 ARG 107 -0.0000

ARG 107 PRO 108 -0.0001

PRO 108 ALA 109 -0.0003

ALA 109 SER 110 0.0001

SER 110 PRO 111 -0.0002

PRO 111 THR 112 0.0003

THR 112 PRO 113 -0.0003

PRO 113 VAL 114 -0.0001

VAL 114 LEU 115 0.0016

LEU 115 ILE 116 0.0002

ILE 116 TRP 117 0.0003

TRP 117 ILE 118 -0.0004

ILE 118 TYR 119 -0.0001

TYR 119 GLY 120 -0.0004

GLY 120 GLY 121 0.0001

GLY 121 GLY 122 -0.0001

GLY 122 PHE 123 0.0000

PHE 123 TYR 124 -0.0002

TYR 124 SER 125 -0.0003

SER 125 GLY 126 0.0052

GLY 126 ALA 127 -0.0000

ALA 127 ALA 128 0.0001

ALA 128 SER 129 -0.0002

SER 129 LEU 130 -0.0001

LEU 130 ASP 131 0.0004

ASP 131 VAL 132 -0.0004

VAL 132 TYR 133 -0.0001

TYR 133 ASP 134 0.0000

ASP 134 GLY 135 -0.0000

GLY 135 ARG 136 -0.0003

ARG 136 PHE 137 0.0020

PHE 137 LEU 138 -0.0004

LEU 138 ALA 139 -0.0001

ALA 139 GLN 140 0.0001

GLN 140 VAL 141 -0.0000

VAL 141 GLU 142 0.0002

GLU 142 GLY 143 0.0002

GLY 143 ALA 144 0.0001

ALA 144 VAL 145 0.0003

VAL 145 LEU 146 0.0001

LEU 146 VAL 147 0.0000

VAL 147 SER 148 0.0047

SER 148 MET 149 0.0001

MET 149 ASN 150 0.0002

ASN 150 TYR 151 -0.0000

TYR 151 ARG 152 -0.0002

ARG 152 VAL 153 0.0002

VAL 153 GLY 154 -0.0001

GLY 154 THR 155 0.0003

THR 155 PHE 156 -0.0003

PHE 156 GLY 157 0.0001

GLY 157 PHE 158 0.0001

PHE 158 LEU 159 0.0040

LEU 159 ALA 160 0.0001

ALA 160 LEU 161 0.0002

LEU 161 PRO 162 -0.0003

PRO 162 GLY 163 0.0004

GLY 163 SER 164 0.0001

SER 164 ARG 165 -0.0004

ARG 165 GLU 166 -0.0003

GLU 166 ALA 167 0.0005

ALA 167 PRO 168 -0.0001

PRO 168 GLY 169 0.0001

GLY 169 ASN 170 0.0043

ASN 170 VAL 171 -0.0000

VAL 171 GLY 172 -0.0000

GLY 172 LEU 173 0.0003

LEU 173 LEU 174 0.0005

LEU 174 ASP 175 0.0002

ASP 175 GLN 176 0.0000

GLN 176 ARG 177 0.0002

ARG 177 LEU 178 0.0002

LEU 178 ALA 179 0.0001

ALA 179 LEU 180 0.0001

LEU 180 GLN 181 0.0049

GLN 181 TRP 182 -0.0000

TRP 182 VAL 183 -0.0003

VAL 183 GLN 184 -0.0001

GLN 184 GLU 185 -0.0002

GLU 185 ASN 186 0.0003

ASN 186 ILE 187 0.0003

ILE 187 ALA 188 0.0004

ALA 188 ALA 189 -0.0004

ALA 189 PHE 190 0.0001

PHE 190 GLY 191 -0.0001

GLY 191 GLY 192 -0.0014

GLY 192 ASP 193 0.0001

ASP 193 PRO 194 0.0001

PRO 194 MET 195 0.0001

MET 195 SER 196 -0.0003

SER 196 VAL 197 -0.0002

VAL 197 THR 198 0.0005

THR 198 LEU 199 0.0002

LEU 199 PHE 200 -0.0002

PHE 200 GLY 201 0.0002

GLY 201 GLU 202 -0.0001

GLU 202 SER 203 0.0090

SER 203 ALA 204 -0.0002

ALA 204 GLY 205 -0.0003

GLY 205 ALA 206 0.0002

ALA 206 ALA 207 -0.0001

ALA 207 SER 208 -0.0001

SER 208 VAL 209 -0.0002

VAL 209 GLY 210 0.0000

GLY 210 MET 211 -0.0001

MET 211 HIS 212 -0.0000

HIS 212 ILE 213 -0.0000

ILE 213 LEU 214 -0.0024

LEU 214 SER 215 0.0001

SER 215 LEU 216 0.0004

LEU 216 PRO 217 0.0000

PRO 217 SER 218 -0.0000

SER 218 ARG 219 -0.0002

ARG 219 SER 220 -0.0000

SER 220 LEU 221 0.0003

LEU 221 PHE 222 0.0002

PHE 222 HIS 223 -0.0001

HIS 223 ARG 224 0.0001

ARG 224 ALA 225 0.0139

ALA 225 VAL 226 0.0000

VAL 226 LEU 227 0.0000

LEU 227 GLN 228 -0.0002

GLN 228 SER 229 -0.0001

SER 229 GLY 230 0.0001

GLY 230 THR 231 -0.0000

THR 231 PRO 232 0.0002

PRO 232 ASN 233 0.0003

ASN 233 GLY 234 0.0002

GLY 234 PRO 235 -0.0000

PRO 235 TRP 236 -0.0002

TRP 236 ALA 237 -0.0003

ALA 237 THR 238 -0.0000

THR 238 VAL 239 0.0001

VAL 239 SER 240 0.0001

SER 240 ALA 241 0.0002

ALA 241 GLY 242 -0.0003

GLY 242 GLU 243 -0.0003

GLU 243 ALA 244 -0.0001

ALA 244 ARG 245 0.0001

ARG 245 ARG 246 -0.0004

ARG 246 ARG 247 0.0010

ARG 247 ALA 248 0.0001

ALA 248 THR 249 0.0000

THR 249 LEU 250 -0.0001

LEU 250 LEU 251 -0.0003

LEU 251 ALA 252 -0.0004

ALA 252 ARG 253 0.0002

ARG 253 LEU 254 0.0003

LEU 254 VAL 255 0.0002

VAL 255 GLY 256 0.0003

GLY 256 CYS 257 -0.0002

CYS 257 PRO 258 0.0025

PRO 258 PRO 259 0.0002

PRO 259 GLY 260 -0.0005

GLY 260 GLY 261 0.0003

GLY 261 ALA 262 0.0001

ALA 262 GLY 263 -0.0001

GLY 263 GLY 264 -0.0000

GLY 264 ASN 265 0.0001

ASN 265 ASP 266 -0.0000

ASP 266 THR 267 -0.0003

THR 267 GLU 268 0.0004

GLU 268 LEU 269 0.0011

LEU 269 ILE 270 0.0001

ILE 270 ALA 271 0.0002

ALA 271 CYS 272 0.0002

CYS 272 LEU 273 -0.0001

LEU 273 ARG 274 0.0003

ARG 274 THR 275 -0.0003

THR 275 ARG 276 -0.0001

ARG 276 PRO 277 0.0002

PRO 277 ALA 278 0.0001

ALA 278 GLN 279 -0.0002

GLN 279 ASP 280 0.0051

ASP 280 LEU 281 0.0001

LEU 281 VAL 282 0.0003

VAL 282 ASP 283 0.0002

ASP 283 HIS 284 -0.0001

HIS 284 GLU 285 0.0002

GLU 285 TRP 286 0.0003

TRP 286 HIS 287 -0.0002

HIS 287 VAL 288 -0.0003

VAL 288 LEU 289 0.0001

LEU 289 PRO 290 0.0004

PRO 290 GLN 291 0.0129

GLN 291 GLU 292 -0.0000

GLU 292 SER 293 0.0000

SER 293 ILE 294 -0.0000

ILE 294 PHE 295 -0.0000

PHE 295 ARG 296 0.0003

ARG 296 PHE 297 -0.0001

PHE 297 SER 298 -0.0003

SER 298 PHE 299 -0.0002

PHE 299 VAL 300 0.0000

VAL 300 PRO 301 0.0003

PRO 301 VAL 302 0.0044

VAL 302 VAL 303 0.0000

VAL 303 ASP 304 -0.0002

ASP 304 GLY 305 -0.0001

GLY 305 ASP 306 -0.0004

ASP 306 PHE 307 0.0004

PHE 307 LEU 308 -0.0004

LEU 308 SER 309 -0.0001

SER 309 ASP 310 0.0002

ASP 310 THR 311 0.0003

THR 311 PRO 312 0.0001

PRO 312 GLU 313 0.0096

GLU 313 ALA 314 0.0000

ALA 314 LEU 315 0.0000

LEU 315 ILE 316 -0.0000

ILE 316 ASN 317 0.0004

ASN 317 THR 318 -0.0002

THR 318 GLY 319 -0.0002

GLY 319 ASP 320 -0.0002

ASP 320 PHE 321 -0.0000

PHE 321 GLN 322 0.0002

GLN 322 ASP 323 0.0003

ASP 323 LEU 324 -0.0378

LEU 324 GLN 325 0.0004

GLN 325 VAL 326 0.0001

VAL 326 LEU 327 -0.0004

LEU 327 VAL 328 0.0004

VAL 328 GLY 329 0.0001

GLY 329 VAL 330 0.0000

VAL 330 VAL 331 0.0002

VAL 331 LYS 332 0.0002

LYS 332 ASP 333 -0.0002

ASP 333 GLU 334 0.0001

GLU 334 GLY 335 -0.0007

GLY 335 SER 336 -0.0002

SER 336 TYR 337 -0.0001

TYR 337 PHE 338 0.0002

PHE 338 LEU 339 0.0001

LEU 339 VAL 340 -0.0004

VAL 340 TYR 341 -0.0002

TYR 341 GLY 342 -0.0000

GLY 342 VAL 343 -0.0001

VAL 343 PRO 344 -0.0001

PRO 344 GLY 345 0.0003

GLY 345 PHE 346 0.0042

PHE 346 SER 347 0.0000

SER 347 LYS 348 0.0001

LYS 348 ASP 349 -0.0002

ASP 349 ASN 350 0.0004

ASN 350 GLU 351 -0.0002

GLU 351 SER 352 -0.0002

SER 352 LEU 353 -0.0000

LEU 353 ILE 354 0.0001

ILE 354 SER 355 0.0002

SER 355 ARG 356 -0.0001

ARG 356 ALA 357 -0.0022

ALA 357 GLN 358 0.0001

GLN 358 PHE 359 -0.0003

PHE 359 LEU 360 -0.0000

LEU 360 ALA 361 0.0003

ALA 361 GLY 362 0.0003

GLY 362 VAL 363 0.0002

VAL 363 ARG 364 -0.0003

ARG 364 ILE 365 -0.0002

ILE 365 GLY 366 0.0001

GLY 366 VAL 367 0.0001

VAL 367 PRO 368 -0.0084

PRO 368 GLN 369 0.0002

GLN 369 ALA 370 -0.0002

ALA 370 SER 371 0.0001

SER 371 ASP 372 0.0001

ASP 372 LEU 373 0.0003

LEU 373 ALA 374 -0.0003

ALA 374 ALA 375 -0.0001

ALA 375 GLU 376 0.0002

GLU 376 ALA 377 0.0002

ALA 377 VAL 378 0.0000

VAL 378 VAL 379 0.0107

VAL 379 LEU 380 0.0002

LEU 380 HIS 381 -0.0000

HIS 381 TYR 382 0.0000

TYR 382 THR 383 0.0002

THR 383 ASP 384 -0.0002

ASP 384 TRP 385 -0.0003

TRP 385 LEU 386 0.0002

LEU 386 HIS 387 -0.0002

HIS 387 PRO 388 0.0003

PRO 388 GLU 389 0.0001

GLU 389 ASP 390 -0.0304

ASP 390 PRO 391 -0.0001

PRO 391 THR 392 -0.0003

THR 392 HIS 393 0.0000

HIS 393 LEU 394 -0.0001

LEU 394 ARG 395 0.0003

ARG 395 ASP 396 0.0000

ASP 396 ALA 397 0.0002

ALA 397 MET 398 0.0005

MET 398 SER 399 -0.0002

SER 399 ALA 400 -0.0002

ALA 400 VAL 401 0.0094

VAL 401 VAL 402 -0.0001

VAL 402 GLY 403 -0.0001

GLY 403 ASP 404 0.0002

ASP 404 HIS 405 -0.0002

HIS 405 ASN 406 0.0003

ASN 406 VAL 407 -0.0001

VAL 407 VAL 408 0.0001

VAL 408 CYS 409 0.0002

CYS 409 PRO 410 0.0002

PRO 410 VAL 411 0.0002

VAL 411 ALA 412 0.0075

ALA 412 GLN 413 0.0001

GLN 413 LEU 414 -0.0003

LEU 414 ALA 415 0.0001

ALA 415 GLY 416 0.0003

GLY 416 ARG 417 0.0003

ARG 417 LEU 418 0.0001

LEU 418 ALA 419 0.0004

ALA 419 ALA 420 0.0000

ALA 420 GLN 421 0.0003

GLN 421 GLY 422 0.0003

GLY 422 ALA 423 -0.0210

ALA 423 ARG 424 0.0000

ARG 424 VAL 425 0.0000

VAL 425 TYR 426 -0.0000

TYR 426 ALA 427 0.0003

ALA 427 TYR 428 0.0000

TYR 428 ILE 429 -0.0004

ILE 429 PHE 430 0.0001

PHE 430 GLU 431 0.0004

GLU 431 HIS 432 -0.0001

HIS 432 ARG 433 -0.0000

ARG 433 ALA 434 0.0047

ALA 434 SER 435 -0.0002

SER 435 THR 436 -0.0000

THR 436 LEU 437 -0.0001

LEU 437 THR 438 0.0004

THR 438 TRP 439 -0.0001

TRP 439 PRO 440 -0.0000

PRO 440 LEU 441 -0.0003

LEU 441 TRP 442 0.0001

TRP 442 MET 443 -0.0001

MET 443 GLY 444 -0.0003

GLY 444 VAL 445 0.0083

VAL 445 PRO 446 -0.0004

PRO 446 HIS 447 -0.0000

HIS 447 GLY 448 0.0003

GLY 448 TYR 449 -0.0003

TYR 449 GLU 450 0.0000

GLU 450 ILE 451 0.0000

ILE 451 GLU 452 0.0003

GLU 452 PHE 453 0.0004

PHE 453 ILE 454 -0.0000

ILE 454 PHE 455 0.0001

PHE 455 GLY 456 0.0022

GLY 456 LEU 457 -0.0003

LEU 457 PRO 458 -0.0001

PRO 458 LEU 459 0.0004

LEU 459 ASP 460 0.0001

ASP 460 PRO 461 -0.0004

PRO 461 SER 462 0.0002

SER 462 LEU 463 -0.0002

LEU 463 ASN 464 0.0004

ASN 464 TYR 465 -0.0000

TYR 465 THR 466 -0.0000

THR 466 THR 467 -0.0008

THR 467 GLU 468 0.0001

GLU 468 GLU 469 -0.0001

GLU 469 ARG 470 -0.0001

ARG 470 ILE 471 -0.0002

ILE 471 PHE 472 -0.0003

PHE 472 ALA 473 -0.0002

ALA 473 GLN 474 0.0003

GLN 474 ARG 475 -0.0001

ARG 475 LEU 476 0.0004

LEU 476 MET 477 -0.0002

MET 477 LYS 478 0.0009

LYS 478 TYR 479 -0.0001

TYR 479 TRP 480 0.0001

TRP 480 THR 481 -0.0002

THR 481 ASN 482 -0.0002

ASN 482 PHE 483 0.0001

PHE 483 ALA 484 -0.0000

ALA 484 ARG 485 0.0001

ARG 485 THR 486 -0.0000

THR 486 GLY 487 0.0001

GLY 487 ASP 488 0.0000

ASP 488 PRO 489 -0.0000

PRO 489 ASN 490 0.0000

ASN 490 ASP 491 0.0001

ASP 491 PRO 492 -0.0002

PRO 492 ARG 493 0.0003

ARG 493 ASP 494 -0.0002

ASP 494 SER 495 0.0002

SER 495 LYS 496 0.0000

LYS 496 SER 497 0.0002

SER 497 PRO 498 -0.0002

PRO 498 GLN 499 -0.0003

GLN 499 TRP 500 -0.0016

TRP 500 PRO 501 -0.0002

PRO 501 PRO 502 0.0006

PRO 502 TYR 503 -0.0001

TYR 503 THR 504 0.0001

THR 504 THR 505 0.0000

THR 505 ALA 506 -0.0002

ALA 506 ALA 507 0.0002

ALA 507 GLN 508 -0.0002

GLN 508 GLN 509 0.0003

GLN 509 TYR 510 -0.0000

TYR 510 VAL 511 -0.0012

VAL 511 SER 512 -0.0000

SER 512 LEU 513 0.0001

LEU 513 ASN 514 -0.0001

ASN 514 LEU 515 -0.0000

LEU 515 LYS 516 -0.0003

LYS 516 PRO 517 0.0002

PRO 517 LEU 518 -0.0001

LEU 518 GLU 519 0.0001

GLU 519 VAL 520 -0.0001

VAL 520 ARG 521 -0.0001

ARG 521 ARG 522 -0.0343

ARG 522 GLY 523 0.0001

GLY 523 LEU 524 0.0002

LEU 524 ARG 525 0.0003

ARG 525 ALA 526 -0.0001

ALA 526 GLN 527 0.0003

GLN 527 THR 528 -0.0003

THR 528 CYS 529 0.0003

CYS 529 ALA 530 0.0003

ALA 530 PHE 531 -0.0003

PHE 531 TRP 532 0.0003

TRP 532 ASN 533 0.0210

ASN 533 ARG 534 0.0000

ARG 534 PHE 535 0.0004

PHE 535 LEU 536 -0.0001

LEU 536 PRO 537 0.0001

PRO 537 LYS 538 0.0000

LYS 538 LEU 539 -0.0002

LEU 539 LEU 540 -0.0000

LEU 540 SER 541 0.0003

SER 541 ALA 542 -0.0005

ALA 542 THR 543 -0.0002

THR 543 ASP 5 0.0246

ASP 5 PRO 6 -0.0001

PRO 6 GLN 7 0.0001

GLN 7 LEU 8 0.0003

LEU 8 LEU 9 0.0004

LEU 9 VAL 10 -0.0002

VAL 10 ARG 11 -0.0002

ARG 11 VAL 12 0.0001

VAL 12 ARG 13 -0.0003

ARG 13 GLY 14 0.0000

GLY 14 GLY 15 0.0002

GLY 15 GLN 16 -0.0019

GLN 16 LEU 17 -0.0000

LEU 17 ARG 18 -0.0004

ARG 18 GLY 19 -0.0001

GLY 19 ILE 20 -0.0002

ILE 20 ARG 21 0.0000

ARG 21 LEU 22 -0.0001

LEU 22 LYS 23 0.0000

LYS 23 ALA 24 0.0000

ALA 24 PRO 25 -0.0001

PRO 25 GLY 26 0.0000

GLY 26 GLY 27 -0.0013

GLY 27 PRO 28 0.0001

PRO 28 VAL 29 -0.0000

VAL 29 SER 30 -0.0004

SER 30 ALA 31 -0.0001

ALA 31 PHE 32 0.0001

PHE 32 LEU 33 0.0002

LEU 33 GLY 34 -0.0002

GLY 34 ILE 35 0.0001

ILE 35 PRO 36 0.0003

PRO 36 PHE 37 0.0001

PHE 37 ALA 38 0.0222

ALA 38 GLU 39 -0.0002

GLU 39 PRO 40 0.0001

PRO 40 PRO 41 0.0004

PRO 41 VAL 42 -0.0003

VAL 42 GLY 43 0.0002

GLY 43 SER 44 0.0001

SER 44 ARG 45 0.0000

ARG 45 ARG 46 -0.0002

ARG 46 PHE 47 0.0001

PHE 47 MET 48 -0.0003

MET 48 PRO 49 0.0068

PRO 49 PRO 50 0.0001

PRO 50 GLU 51 0.0001

GLU 51 PRO 52 0.0002

PRO 52 LYS 53 -0.0002

LYS 53 ARG 54 0.0001

ARG 54 PRO 55 -0.0002

PRO 55 TRP 56 -0.0002

TRP 56 SER 57 0.0003

SER 57 GLY 58 -0.0003

GLY 58 VAL 59 -0.0001

VAL 59 LEU 60 0.0020

LEU 60 ASP 61 -0.0002

ASP 61 ALA 62 0.0000

ALA 62 THR 63 -0.0000

THR 63 THR 64 -0.0001

THR 64 PHE 65 0.0003

PHE 65 GLN 66 -0.0001

GLN 66 ASN 67 -0.0001

ASN 67 VAL 68 -0.0001

VAL 68 CYS 69 -0.0000

CYS 69 TYR 70 0.0001

TYR 70 GLN 71 -0.0025

GLN 71 TYR 72 0.0001

TYR 72 VAL 73 -0.0003

VAL 73 ASP 74 0.0002

ASP 74 THR 75 0.0000

THR 75 LEU 76 0.0001

LEU 76 TYR 77 0.0002

TYR 77 PRO 78 0.0003

PRO 78 GLY 79 0.0000

GLY 79 PHE 80 0.0004

PHE 80 GLU 81 -0.0003

GLU 81 GLY 82 0.0071

GLY 82 THR 83 -0.0003

THR 83 GLU 84 0.0003

GLU 84 MET 85 -0.0003

MET 85 TRP 86 -0.0002

TRP 86 ASN 87 0.0001

ASN 87 PRO 88 -0.0000

PRO 88 ASN 89 0.0003

ASN 89 ARG 90 -0.0000

ARG 90 GLU 91 0.0001

GLU 91 LEU 92 -0.0001

LEU 92 SER 93 -0.0139

SER 93 GLU 94 0.0002

GLU 94 ASP 95 0.0002

ASP 95 CYS 96 -0.0001

CYS 96 LEU 97 0.0003

LEU 97 TYR 98 0.0001

TYR 98 LEU 99 -0.0003

LEU 99 ASN 100 0.0002

ASN 100 VAL 101 0.0002

VAL 101 TRP 102 -0.0001

TRP 102 THR 103 0.0005

THR 103 PRO 104 0.0063

PRO 104 TYR 105 0.0003

TYR 105 PRO 106 -0.0002

PRO 106 ARG 107 0.0002

ARG 107 PRO 108 -0.0003

PRO 108 ALA 109 -0.0001

ALA 109 SER 110 0.0001

SER 110 PRO 111 0.0001

PRO 111 THR 112 -0.0004

THR 112 PRO 113 -0.0002

PRO 113 VAL 114 0.0000

VAL 114 LEU 115 -0.0053

LEU 115 ILE 116 0.0004

ILE 116 TRP 117 0.0000

TRP 117 ILE 118 -0.0002

ILE 118 TYR 119 0.0001

TYR 119 GLY 120 -0.0000

GLY 120 GLY 121 0.0001

GLY 121 GLY 122 0.0000

GLY 122 PHE 123 0.0001

PHE 123 TYR 124 0.0003

TYR 124 SER 125 0.0002

SER 125 GLY 126 -0.0020

GLY 126 ALA 127 -0.0001

ALA 127 ALA 128 0.0003

ALA 128 SER 129 -0.0000

SER 129 LEU 130 0.0002

LEU 130 ASP 131 0.0001

ASP 131 VAL 132 -0.0002

VAL 132 TYR 133 -0.0001

TYR 133 ASP 134 0.0005

ASP 134 GLY 135 -0.0002

GLY 135 ARG 136 0.0001

ARG 136 PHE 137 0.0031

PHE 137 LEU 138 -0.0002

LEU 138 ALA 139 0.0002

ALA 139 GLN 140 0.0003

GLN 140 VAL 141 0.0003

VAL 141 GLU 142 -0.0002

GLU 142 GLY 143 0.0001

GLY 143 ALA 144 0.0001

ALA 144 VAL 145 0.0005

VAL 145 LEU 146 -0.0004

LEU 146 VAL 147 0.0000

VAL 147 SER 148 0.0008

SER 148 MET 149 0.0004

MET 149 ASN 150 -0.0004

ASN 150 TYR 151 0.0000

TYR 151 ARG 152 -0.0003

ARG 152 VAL 153 -0.0002

VAL 153 GLY 154 0.0001

GLY 154 THR 155 0.0001

THR 155 PHE 156 0.0004

PHE 156 GLY 157 -0.0002

GLY 157 PHE 158 0.0003

PHE 158 LEU 159 -0.0056

LEU 159 ALA 160 -0.0001

ALA 160 LEU 161 0.0001

LEU 161 PRO 162 0.0001

PRO 162 GLY 163 0.0001

GLY 163 SER 164 -0.0001

SER 164 ARG 165 -0.0003

ARG 165 GLU 166 0.0002

GLU 166 ALA 167 -0.0001

ALA 167 PRO 168 -0.0003

PRO 168 GLY 169 0.0000

GLY 169 ASN 170 0.0049

ASN 170 VAL 171 0.0004

VAL 171 GLY 172 -0.0002

GLY 172 LEU 173 -0.0001

LEU 173 LEU 174 0.0002

LEU 174 ASP 175 -0.0001

ASP 175 GLN 176 -0.0000

GLN 176 ARG 177 0.0001

ARG 177 LEU 178 -0.0000

LEU 178 ALA 179 0.0000

ALA 179 LEU 180 -0.0003

LEU 180 GLN 181 -0.0035

GLN 181 TRP 182 0.0001

TRP 182 VAL 183 0.0000

VAL 183 GLN 184 0.0001

GLN 184 GLU 185 0.0002

GLU 185 ASN 186 0.0001

ASN 186 ILE 187 0.0000

ILE 187 ALA 188 -0.0001

ALA 188 ALA 189 -0.0002

ALA 189 PHE 190 -0.0005

PHE 190 GLY 191 0.0003

GLY 191 GLY 192 0.0002

GLY 192 ASP 193 0.0004

ASP 193 PRO 194 0.0000

PRO 194 MET 195 0.0000

MET 195 SER 196 0.0000

SER 196 VAL 197 0.0001

VAL 197 THR 198 -0.0002

THR 198 LEU 199 0.0002

LEU 199 PHE 200 -0.0001

PHE 200 GLY 201 -0.0003

GLY 201 GLU 202 0.0002

GLU 202 SER 203 -0.0031

SER 203 ALA 204 -0.0000

ALA 204 GLY 205 0.0003

GLY 205 ALA 206 0.0002

ALA 206 ALA 207 -0.0001

ALA 207 SER 208 -0.0001

SER 208 VAL 209 -0.0002

VAL 209 GLY 210 -0.0002

GLY 210 MET 211 0.0001

MET 211 HIS 212 0.0003

HIS 212 ILE 213 -0.0003

ILE 213 LEU 214 0.0020

LEU 214 SER 215 -0.0003

SER 215 LEU 216 0.0000

LEU 216 PRO 217 0.0004

PRO 217 SER 218 0.0001

SER 218 ARG 219 0.0002

ARG 219 SER 220 0.0000

SER 220 LEU 221 0.0003

LEU 221 PHE 222 0.0003

PHE 222 HIS 223 -0.0004

HIS 223 ARG 224 0.0003

ARG 224 ALA 225 0.0023

ALA 225 VAL 226 -0.0001

VAL 226 LEU 227 -0.0003

LEU 227 GLN 228 -0.0001

GLN 228 SER 229 -0.0003

SER 229 GLY 230 -0.0002

GLY 230 THR 231 0.0002

THR 231 PRO 232 -0.0002

PRO 232 ASN 233 -0.0003

ASN 233 GLY 234 0.0003

GLY 234 PRO 235 0.0001

PRO 235 TRP 236 -0.0252

TRP 236 ALA 237 0.0003

ALA 237 THR 238 0.0000

THR 238 VAL 239 -0.0001

VAL 239 SER 240 0.0001

SER 240 ALA 241 -0.0000

ALA 241 GLY 242 0.0002

GLY 242 GLU 243 0.0001

GLU 243 ALA 244 -0.0000

ALA 244 ARG 245 0.0004

ARG 245 ARG 246 0.0003

ARG 246 ARG 247 0.0204

ARG 247 ALA 248 0.0001

ALA 248 THR 249 0.0002

THR 249 LEU 250 -0.0001

LEU 250 LEU 251 0.0003

LEU 251 ALA 252 -0.0001

ALA 252 ARG 253 0.0001

ARG 253 LEU 254 0.0000

LEU 254 VAL 255 -0.0000

VAL 255 GLY 256 0.0000

GLY 256 CYS 257 0.0000

CYS 257 PRO 258 -0.0278

PRO 258 PRO 259 -0.0002

PRO 259 GLY 260 -0.0002

GLY 260 GLY 261 0.0002

GLY 261 ALA 262 -0.0002

ALA 262 GLY 263 -0.0000

GLY 263 GLY 264 0.0001

GLY 264 ASN 265 -0.0002

ASN 265 ASP 266 0.0002

ASP 266 THR 267 0.0002

THR 267 GLU 268 0.0000

GLU 268 LEU 269 -0.0131

LEU 269 ILE 270 -0.0001

ILE 270 ALA 271 -0.0003

ALA 271 CYS 272 0.0003

CYS 272 LEU 273 -0.0004

LEU 273 ARG 274 0.0001

ARG 274 THR 275 -0.0001

THR 275 ARG 276 0.0004

ARG 276 PRO 277 -0.0002

PRO 277 ALA 278 0.0002

ALA 278 GLN 279 0.0003

GLN 279 ASP 280 0.0142

ASP 280 LEU 281 -0.0000

LEU 281 VAL 282 0.0001

VAL 282 ASP 283 0.0002

ASP 283 HIS 284 -0.0004

HIS 284 GLU 285 0.0001

GLU 285 TRP 286 0.0001

TRP 286 HIS 287 0.0003

HIS 287 VAL 288 -0.0001

VAL 288 LEU 289 0.0000

LEU 289 PRO 290 0.0001

PRO 290 GLN 291 -0.0096

GLN 291 GLU 292 0.0002

GLU 292 SER 293 -0.0002

SER 293 ILE 294 0.0003

ILE 294 PHE 295 -0.0001

PHE 295 ARG 296 0.0002

ARG 296 PHE 297 -0.0002

PHE 297 SER 298 0.0003

SER 298 PHE 299 0.0004

PHE 299 VAL 300 -0.0003

VAL 300 PRO 301 0.0000

PRO 301 VAL 302 -0.0063

VAL 302 VAL 303 0.0000

VAL 303 ASP 304 -0.0001

ASP 304 GLY 305 -0.0001

GLY 305 ASP 306 0.0001

ASP 306 PHE 307 0.0001

PHE 307 LEU 308 -0.0000

LEU 308 SER 309 0.0001

SER 309 ASP 310 0.0002

ASP 310 THR 311 -0.0002

THR 311 PRO 312 -0.0004

PRO 312 GLU 313 -0.0047

GLU 313 ALA 314 0.0003

ALA 314 LEU 315 0.0002

LEU 315 ILE 316 -0.0002

ILE 316 ASN 317 -0.0002

ASN 317 THR 318 0.0002

THR 318 GLY 319 0.0002

GLY 319 ASP 320 0.0004

ASP 320 PHE 321 -0.0003

PHE 321 GLN 322 0.0004

GLN 322 ASP 323 -0.0003

ASP 323 LEU 324 0.0046

LEU 324 GLN 325 0.0001

GLN 325 VAL 326 0.0001

VAL 326 LEU 327 -0.0003

LEU 327 VAL 328 0.0006

VAL 328 GLY 329 -0.0002

GLY 329 VAL 330 -0.0001

VAL 330 VAL 331 0.0002

VAL 331 LYS 332 -0.0002

LYS 332 ASP 333 0.0002

ASP 333 GLU 334 0.0000

GLU 334 GLY 335 0.0061

GLY 335 SER 336 -0.0002

SER 336 TYR 337 -0.0002

TYR 337 PHE 338 -0.0004

PHE 338 LEU 339 -0.0000

LEU 339 VAL 340 -0.0002

VAL 340 TYR 341 -0.0003

TYR 341 GLY 342 -0.0000

GLY 342 VAL 343 -0.0000

VAL 343 PRO 344 -0.0001

PRO 344 GLY 345 0.0001

GLY 345 PHE 346 -0.0026

PHE 346 SER 347 -0.0000

SER 347 LYS 348 -0.0001

LYS 348 ASP 349 -0.0003

ASP 349 ASN 350 0.0002

ASN 350 GLU 351 0.0000

GLU 351 SER 352 -0.0003

SER 352 LEU 353 0.0000

LEU 353 ILE 354 -0.0001

ILE 354 SER 355 0.0001

SER 355 ARG 356 0.0000

ARG 356 ALA 357 0.0006

ALA 357 GLN 358 0.0002

GLN 358 PHE 359 -0.0003

PHE 359 LEU 360 0.0003

LEU 360 ALA 361 -0.0002

ALA 361 GLY 362 0.0002

GLY 362 VAL 363 -0.0002

VAL 363 ARG 364 0.0003

ARG 364 ILE 365 0.0000

ILE 365 GLY 366 0.0002

GLY 366 VAL 367 0.0001

VAL 367 PRO 368 -0.0013

PRO 368 GLN 369 0.0002

GLN 369 ALA 370 -0.0000

ALA 370 SER 371 0.0004

SER 371 ASP 372 0.0003

ASP 372 LEU 373 0.0002

LEU 373 ALA 374 0.0004

ALA 374 ALA 375 0.0001

ALA 375 GLU 376 0.0004

GLU 376 ALA 377 -0.0001

ALA 377 VAL 378 -0.0001

VAL 378 VAL 379 -0.0053

VAL 379 LEU 380 0.0005

LEU 380 HIS 381 0.0002

HIS 381 TYR 382 -0.0000

TYR 382 THR 383 0.0001

THR 383 ASP 384 0.0000

ASP 384 TRP 385 0.0000

TRP 385 LEU 386 0.0001

LEU 386 HIS 387 0.0004

HIS 387 PRO 388 -0.0001

PRO 388 GLU 389 0.0002

GLU 389 ASP 390 0.0120

ASP 390 PRO 391 0.0001

PRO 391 THR 392 0.0002

THR 392 HIS 393 0.0001

HIS 393 LEU 394 0.0000

LEU 394 ARG 395 0.0001

ARG 395 ASP 396 0.0002

ASP 396 ALA 397 -0.0000

ALA 397 MET 398 -0.0001

MET 398 SER 399 0.0000

SER 399 ALA 400 -0.0003

ALA 400 VAL 401 -0.0086

VAL 401 VAL 402 0.0001

VAL 402 GLY 403 0.0003

GLY 403 ASP 404 0.0001

ASP 404 HIS 405 -0.0001

HIS 405 ASN 406 -0.0001

ASN 406 VAL 407 -0.0001

VAL 407 VAL 408 -0.0004

VAL 408 CYS 409 -0.0002

CYS 409 PRO 410 -0.0001

PRO 410 VAL 411 0.0002

VAL 411 ALA 412 -0.0065

ALA 412 GLN 413 -0.0001

GLN 413 LEU 414 -0.0001

LEU 414 ALA 415 0.0000

ALA 415 GLY 416 0.0002

GLY 416 ARG 417 -0.0000

ARG 417 LEU 418 0.0000

LEU 418 ALA 419 -0.0001

ALA 419 ALA 420 0.0005

ALA 420 GLN 421 -0.0002

GLN 421 GLY 422 -0.0004

GLY 422 ALA 423 -0.0063

ALA 423 ARG 424 -0.0001

ARG 424 VAL 425 -0.0001

VAL 425 TYR 426 0.0002

TYR 426 ALA 427 -0.0000

ALA 427 TYR 428 0.0003

TYR 428 ILE 429 -0.0002

ILE 429 PHE 430 0.0004

PHE 430 GLU 431 0.0003

GLU 431 HIS 432 -0.0002

HIS 432 ARG 433 -0.0001

ARG 433 ALA 434 -0.0050

ALA 434 SER 435 0.0000

SER 435 THR 436 0.0001

THR 436 LEU 437 -0.0001

LEU 437 THR 438 -0.0002

THR 438 TRP 439 0.0003

TRP 439 PRO 440 -0.0003

PRO 440 LEU 441 0.0002

LEU 441 TRP 442 0.0002

TRP 442 MET 443 0.0002

MET 443 GLY 444 0.0000

GLY 444 VAL 445 0.0053

VAL 445 PRO 446 -0.0002

PRO 446 HIS 447 -0.0001

HIS 447 GLY 448 0.0001

GLY 448 TYR 449 0.0004

TYR 449 GLU 450 -0.0001

GLU 450 ILE 451 0.0001

ILE 451 GLU 452 0.0002

GLU 452 PHE 453 0.0002

PHE 453 ILE 454 0.0002

ILE 454 PHE 455 -0.0003

PHE 455 GLY 456 -0.0023

GLY 456 LEU 457 0.0000

LEU 457 PRO 458 0.0001

PRO 458 LEU 459 -0.0000

LEU 459 ASP 460 -0.0003

ASP 460 PRO 461 -0.0002

PRO 461 SER 462 0.0000

SER 462 LEU 463 -0.0003

LEU 463 ASN 464 0.0002

ASN 464 TYR 465 -0.0002

TYR 465 THR 466 0.0002

THR 466 THR 467 -0.0025

THR 467 GLU 468 -0.0001

GLU 468 GLU 469 -0.0002

GLU 469 ARG 470 -0.0002

ARG 470 ILE 471 -0.0001

ILE 471 PHE 472 -0.0004

PHE 472 ALA 473 0.0000

ALA 473 GLN 474 -0.0003

GLN 474 ARG 475 -0.0001

ARG 475 LEU 476 0.0001

LEU 476 MET 477 0.0001

MET 477 LYS 478 -0.0006

LYS 478 TYR 479 0.0001

TYR 479 TRP 480 0.0003

TRP 480 THR 481 -0.0000

THR 481 ASN 482 0.0002

ASN 482 PHE 483 0.0005

PHE 483 ALA 484 0.0002

ALA 484 ARG 485 -0.0004

ARG 485 THR 486 -0.0001

THR 486 GLY 487 -0.0002

GLY 487 ASP 488 0.0001

ASP 488 PRO 489 0.0013

PRO 489 ASN 490 -0.0001

ASN 490 ASP 491 0.0003

ASP 491 PRO 492 -0.0000

PRO 492 ARG 493 -0.0004

ARG 493 ASP 494 0.0003

ASP 494 SER 495 -0.0003

SER 495 LYS 496 -0.0002

LYS 496 SER 497 -0.0004

SER 497 PRO 498 -0.0003

PRO 498 GLN 499 0.0001

GLN 499 TRP 500 -0.0014

TRP 500 PRO 501 0.0001

PRO 501 PRO 502 -0.0002

PRO 502 TYR 503 0.0001

TYR 503 THR 504 -0.0001

THR 504 THR 505 -0.0000

THR 505 ALA 506 -0.0003

ALA 506 ALA 507 0.0002

ALA 507 GLN 508 0.0004

GLN 508 GLN 509 0.0001

GLN 509 TYR 510 -0.0002

TYR 510 VAL 511 0.0025

VAL 511 SER 512 -0.0002

SER 512 LEU 513 -0.0002

LEU 513 ASN 514 0.0002

ASN 514 LEU 515 -0.0003

LEU 515 LYS 516 0.0003

LYS 516 PRO 517 -0.0001

PRO 517 LEU 518 -0.0002

LEU 518 GLU 519 0.0000

GLU 519 VAL 520 0.0002

VAL 520 ARG 521 -0.0001

ARG 521 ARG 522 0.0405

ARG 522 GLY 523 0.0000

GLY 523 LEU 524 -0.0002

LEU 524 ARG 525 -0.0003

ARG 525 ALA 526 -0.0001

ALA 526 GLN 527 -0.0001

GLN 527 THR 528 -0.0001

THR 528 CYS 529 0.0001

CYS 529 ALA 530 0.0002

ALA 530 PHE 531 -0.0002

PHE 531 TRP 532 0.0002

TRP 532 ASN 533 -0.0014

ASN 533 ARG 534 -0.0001

ARG 534 PHE 535 0.0002

PHE 535 LEU 536 -0.0005

LEU 536 PRO 537 -0.0002

PRO 537 LYS 538 0.0005

LYS 538 LEU 539 -0.0002

LEU 539 LEU 540 0.0001

LEU 540 SER 541 0.0005

SER 541 ALA 542 -0.0002

ALA 542 THR 543 0.0002

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Between 2015 and 2025, it was hosted by US2B (Nantes).
Last modification: april 24th, 2026.

Should you encounter any unexpected behaviour, please let us know. elNémo has been relocated. **Some cleaning from time to time** Sorry for the inconvenience.

*** HYDROLASE 26-JUL-99 1C2O ***

CA strain for 2610021235441786978

--- normal mode 11 ---

Should you encounter any unexpected behaviour,
please let us know.
elNémo has been relocated.
Some cleaning from time to time
Sorry for the inconvenience.

* HYDROLASE 26-JUL-99 1C2O *