Should you encounter any unexpected behaviour,
please let us know.
elNémo has been relocated.
Some cleaning from time to time
Sorry for the inconvenience.

* HYDROLASE/HYDROLASE INHIBITOR 26-APR-00 1EWM *

CA distance fluctuations for 2610021246531795849

--- normal mode 14 ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok

largest increase ref largest decrease
GLU 184 0.53 ALA 1 -0.36 ALA 118

GLU 184 0.60 PRO 2 -0.70 ALA 118

GLU 184 0.74 ALA 3 -0.70 ALA 118

GLU 184 0.86 ALA 4 -0.41 ALA 118

GLU 184 0.61 VAL 5 -0.25 VAL 148

GLU 184 0.70 ASP 6 -0.35 GLY 147

GLU 184 0.51 TRP 7 -0.31 GLY 147

THR 179 0.67 ARG 8 -0.33 GLY 147

ALA 4 0.73 ALA 9 -0.34 GLY 147

THR 179 0.55 ARG 10 -0.29 GLY 147

THR 179 0.61 GLY 11 -0.21 GLY 147

THR 179 0.50 ALA 12 -0.21 GLY 147

THR 179 0.49 VAL 13 -0.23 GLY 147

ALA 15 0.54 THR 14 -0.19 GLY 147

THR 14 0.54 ALA 15 -0.27 PRO 87

ALA 167 0.54 VAL 16 -0.33 PRO 87

ALA 167 0.40 LYS 17 -0.32 GLY 185

ALA 167 0.37 ASP 18 -0.59 THR 178

ASN 47 0.26 GLN 19 -0.62 THR 178

ALA 167 0.24 GLY 20 -0.91 GLN 180

ASN 47 0.23 GLN 21 -0.95 GLN 180

GLN 156 0.29 CYS 22 -0.75 GLN 180

GLN 156 0.36 GLY 23 -0.67 GLN 180

ASP 158 0.36 SER 24 -0.53 GLN 180

ASP 158 0.42 CYS 25 -0.53 TRP 177

ASP 158 0.43 TRP 26 -0.36 TRP 177

ASP 158 0.35 ALA 27 -0.30 GLN 180

ASP 158 0.36 PHE 28 -0.27 THR 178

GLY 160 0.38 SER 29 -0.22 TRP 177

ASP 158 0.30 ALA 30 -0.20 ALA 121

ASP 158 0.30 ILE 31 -0.17 ALA 121

ASP 158 0.31 GLY 32 -0.17 GLY 147

ASP 158 0.26 ASN 33 -0.17 ALA 121

ASP 158 0.24 VAL 34 -0.17 LEU 48

ASP 158 0.25 GLU 35 -0.15 ASN 127

THR 179 0.33 CYS 36 -0.19 ASN 127

THR 179 0.28 GLN 37 -0.20 TRP 123

THR 179 0.29 TRP 38 -0.17 TRP 123

THR 179 0.37 PHE 39 -0.27 ASN 127

GLY 212 0.41 LEU 40 -0.42 ASN 127

GLY 212 0.37 ALA 41 -0.39 ASN 127

THR 179 0.35 GLY 42 -0.34 ASN 127

THR 179 0.36 HIS 43 -0.26 ASN 127

THR 179 0.43 PRO 44 -0.22 ASN 127

THR 179 0.43 LEU 45 -0.21 ASN 127

THR 179 0.33 THR 46 -0.17 ASN 127

ALA 167 0.30 ASN 47 -0.15 ASN 127

ASP 158 0.26 LEU 48 -0.17 VAL 34

ASP 158 0.24 SER 49 -0.19 THR 178

ASP 158 0.29 GLU 50 -0.32 THR 178

GLN 156 0.26 GLN 51 -0.41 THR 178

GLN 156 0.24 MET 52 -0.32 GLN 180

GLN 156 0.28 LEU 53 -0.35 GLN 180

GLN 156 0.29 VAL 54 -0.48 GLN 180

GLN 156 0.26 SER 55 -0.48 GLN 180

GLN 156 0.24 CYS 56 -0.38 GLN 180

GLN 156 0.24 ASP 57 -0.37 GLN 180

GLN 156 0.23 LYS 58 -0.41 GLN 180

GLN 156 0.24 THR 59 -0.35 GLN 180

GLN 156 0.29 ASP 60 -0.41 GLN 180

GLN 156 0.28 SER 61 -0.49 GLN 180

GLN 156 0.30 GLY 62 -0.53 GLN 180

GLN 156 0.32 CYS 63 -0.62 GLN 180

GLN 156 0.31 SER 64 -0.62 GLN 180

GLN 156 0.38 GLY 65 -0.53 GLN 180

GLN 156 0.38 GLY 66 -0.41 GLN 180

GLN 156 0.39 LEU 67 -0.32 GLN 180

GLN 156 0.33 MET 68 -0.26 TRP 177

GLN 156 0.25 ASN 69 -0.23 TRP 177

GLN 156 0.25 ASN 70 -0.26 TRP 177

GLN 156 0.27 ALA 71 -0.27 TRP 177

GLN 156 0.23 PHE 72 -0.19 TRP 177

GLN 156 0.18 GLU 73 -0.20 TRP 177

GLN 156 0.19 TRP 74 -0.24 GLN 180

GLN 156 0.19 ILE 75 -0.18 TRP 177

LEU 40 0.21 VAL 76 -0.15 PRO 114

LEU 40 0.19 GLN 77 -0.18 TRP 177

LEU 40 0.17 GLU 78 -0.23 GLN 180

LEU 40 0.18 ASN 78 -0.19 GLN 180

LEU 40 0.23 ASN 78 -0.13 PRO 114

THR 106 0.35 GLY 78 -0.15 LEU 113

PHE 39 0.21 ALA 79 -0.16 LEU 113

GLN 156 0.21 VAL 80 -0.17 LEU 113

GLN 156 0.20 TYR 81 -0.15 LEU 113

ALA 89 0.24 THR 82 -0.17 ALA 209

ALA 89 0.29 GLU 83 -0.18 GLU 183

ALA 89 0.31 ASP 84 -0.17 GLU 183

ALA 89 0.23 SER 85 -0.19 GLU 183

ALA 89 0.27 TYR 86 -0.27 GLN 180

ALA 89 0.36 PRO 87 -0.36 THR 178

ALA 89 0.29 TYR 88 -0.46 THR 178

PRO 87 0.36 ALA 89 -0.60 GLN 180

GLN 156 0.25 SER 89 -0.68 GLN 180

TYR 88 0.29 GLY 89 -0.86 GLN 180

ASP 84 0.23 GLU 89 -0.87 GLN 180

GLN 156 0.27 GLY 90 -0.78 GLN 180

GLN 156 0.25 ILE 91 -0.68 GLN 180

GLN 156 0.26 SER 92 -0.60 GLN 180

GLN 156 0.24 PRO 93 -0.58 GLN 180

GLN 156 0.25 PRO 94 -0.49 GLN 180

GLN 156 0.22 CYS 95 -0.44 GLN 180

GLN 156 0.19 THR 96 -0.39 GLN 180

GLN 156 0.19 THR 97 -0.30 GLN 180

GLN 156 0.18 SER 98 -0.25 GLN 180

GLN 156 0.17 GLY 99 -0.22 GLN 180

GLN 156 0.18 HIS 100 -0.17 GLN 180

ALA 167 0.20 THR 101 -0.14 LEU 113

HIS 43 0.22 VAL 102 -0.15 LEU 113

ALA 167 0.22 GLY 103 -0.17 ALA 209

PHE 39 0.23 ALA 105 -0.16 GLY 103

GLY 78 0.35 THR 106 -0.17 ILE 107

LEU 40 0.28 ILE 107 -0.17 THR 106

LEU 40 0.25 THR 108 -0.24 GLY 109

ASN 127 0.21 GLY 109 -0.24 THR 108

ASN 127 0.21 HIS 110 -0.22 LEU 113

ASN 127 0.17 VAL 111 -0.25 VAL 210

GLN 156 0.13 GLU 112 -0.43 LEU 113

SER 152 0.15 LEU 113 -0.43 GLU 112

SER 152 0.21 PRO 114 -0.40 ASP 167

SER 152 0.26 GLN 115 -0.49 ASP 167

SER 193 0.31 ASP 116 -0.60 ASP 167

THR 151 0.29 GLU 117 -0.65 ASP 167

GLU 184 0.33 ALA 118 -0.70 ALA 3

GLU 184 0.28 GLN 119 -0.57 PRO 2

GLU 184 0.28 ILE 120 -0.41 ALA 3

GLU 184 0.37 ALA 121 -0.39 ILE 120

GLU 184 0.35 ALA 122 -0.45 PRO 2

GLU 184 0.29 TRP 123 -0.34 ALA 122

GLU 184 0.34 LEU 124 -0.24 ALA 41

GLU 184 0.41 ALA 125 -0.14 ALA 3

GLU 184 0.33 VAL 126 -0.25 LEU 40

GLU 184 0.26 ASN 127 -0.42 LEU 40

GLU 184 0.30 GLY 128 -0.18 GLY 147

THR 179 0.28 PRO 129 -0.18 GLY 147

THR 179 0.18 VAL 130 -0.24 ALA 121

GLN 156 0.22 ALA 131 -0.24 ALA 121

ALA 133 0.29 VAL 132 -0.30 LYS 191

VAL 132 0.29 ALA 133 -0.35 GLY 160

SER 155 0.19 VAL 134 -0.42 LYS 191

VAL 161 0.25 ASP 135 -0.46 VAL 168

LYS 174 0.20 ALA 136 -0.28 PRO 169

ASP 18 0.22 SER 139 -0.32 VAL 168

ASP 18 0.13 SER 140 -0.28 VAL 168

ILE 187 0.16 TRP 141 -0.28 GLN 180

ALA 167 0.21 MET 142 -0.43 GLN 180

ALA 167 0.18 THR 143 -0.34 GLN 180

ALA 167 0.28 TYR 144 -0.31 GLU 184

ALA 167 0.48 THR 145 -0.41 GLU 184

ALA 167 0.62 GLY 146 -0.31 GLU 183

GLY 146 0.57 GLY 147 -0.35 ASP 6

LYS 191 0.39 VAL 148 -0.32 ASP 6

SER 193 0.30 MET 149 -0.24 ASP 6

SER 193 0.48 THR 151 -0.35 VAL 168

SER 193 0.35 SER 152 -0.55 VAL 168

GLN 115 0.15 CYS 153 -0.63 VAL 168

GLU 204 0.14 VAL 154 -0.66 VAL 168

LEU 67 0.20 SER 155 -0.85 VAL 168

LEU 67 0.29 GLU 156 -0.76 VAL 168

TRP 26 0.40 GLN 156 -0.60 VAL 168

GLN 156 0.35 LEU 157 -0.46 VAL 168

TRP 26 0.43 ASP 158 -0.33 VAL 168

ASP 158 0.40 HIS 159 -0.33 ALA 133

SER 29 0.38 GLY 160 -0.35 ALA 133

GLY 160 0.36 VAL 161 -0.19 LYS 191

ASP 158 0.23 LEU 162 -0.19 GLY 147

THR 179 0.23 LEU 163 -0.19 GLY 147

THR 179 0.38 VAL 164 -0.28 GLY 147

GLU 184 0.53 GLY 165 -0.28 ASP 6

GLU 184 0.65 TYR 166 -0.27 SER 155

GLU 184 0.98 ASN 167 -0.43 ASN 198

GLU 184 0.78 ASP 167 -0.87 GLY 192

GLU 184 0.97 SER 167 -0.70 SER 193

GLU 184 1.14 ALA 167 -0.67 SER 193

GLU 184 0.94 ALA 167 -0.78 SER 193

GLU 183 0.78 VAL 168 -1.10 SER 193

GLU 184 0.63 PRO 169 -0.84 SER 193

GLU 184 0.56 TYR 170 -0.52 GLN 199

GLU 184 0.45 TRP 171 -0.25 SER 155

TYR 186 0.54 ILE 172 -0.35 ARG 188

ASN 167 0.32 ILE 173 -0.26 GLY 147

ASN 167 0.37 LYS 174 -0.23 GLY 147

ALA 167 0.33 ASN 175 -0.26 GLU 183

ALA 167 0.34 SER 176 -0.31 CYS 25

ALA 167 0.44 TRP 177 -0.61 GLY 23

ALA 167 0.61 THR 178 -0.75 GLY 20

ALA 167 0.89 THR 179 -0.60 GLY 89

ALA 167 0.99 GLN 180 -0.95 GLN 21

ALA 167 0.69 TRP 181 -0.51 GLN 21

ALA 167 0.74 GLY 182 -0.38 GLU 184

ALA 167 1.02 GLU 183 -0.40 THR 145

ALA 167 1.14 GLU 184 -0.51 GLY 89

ALA 167 0.70 GLY 185 -0.34 GLY 89

ALA 167 0.64 TYR 186 -0.33 GLU 183

ALA 167 0.38 ILE 187 -0.29 GLY 147

GLY 182 0.38 ARG 188 -0.35 ILE 172

GLY 192 0.27 ILE 189 -0.31 CYS 153

LYS 191 0.51 ALA 190 -0.55 SER 155

ALA 190 0.51 LYS 191 -0.86 ASN 198

ALA 190 0.43 GLY 192 -0.87 ASP 167

THR 151 0.48 SER 193 -1.10 VAL 168

SER 152 0.29 ASN 198 -0.86 LYS 191

SER 152 0.33 GLN 199 -0.75 VAL 168

CYS 153 0.14 CYS 200 -0.60 VAL 168

GLU 204 0.18 LEU 201 -0.69 LYS 191

ILE 173 0.19 VAL 202 -0.52 LYS 191

SER 152 0.22 LYS 203 -0.55 ASP 167

SER 155 0.19 GLU 204 -0.50 ASP 167

SER 155 0.20 GLU 205 -0.38 ASP 167

SER 155 0.13 ALA 206 -0.35 ASP 167

GLN 156 0.18 SER 207 -0.28 ALA 121

GLN 156 0.18 SER 208 -0.22 ALA 121

GLY 128 0.20 ALA 209 -0.17 LEU 113

GLY 128 0.28 VAL 210 -0.25 VAL 111

LEU 40 0.27 VAL 211 -0.18 LEU 113

LEU 40 0.41 GLY 212 -0.18 VAL 111

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Between 2015 and 2025, it was hosted by US2B (Nantes).
Last modification: april 24th, 2026.

Should you encounter any unexpected behaviour, please let us know. elNémo has been relocated. **Some cleaning from time to time** Sorry for the inconvenience.

*** HYDROLASE/HYDROLASE INHIBITOR 26-APR-00 1EWM ***

CA distance fluctuations for 2610021246531795849

--- normal mode 14 ---

Should you encounter any unexpected behaviour,
please let us know.
elNémo has been relocated.
Some cleaning from time to time
Sorry for the inconvenience.

* HYDROLASE/HYDROLASE INHIBITOR 26-APR-00 1EWM *